David John Adams

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Distinguished Professor

University of Wollongong

Australia

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David John Adams is a Distinguished Professor at the University of Wollongong, Australia. His research focuses on the neuromodulation and ion channel function related to conditions such as Parkinson's disease and chemotherapy-induced neuropathic pain. Recent articles highlight his work on spider venom peptides, α-conotoxins, and their impact on human nicotinic acetylcholine receptors and GABAB receptor modulation.

Recent Grants

Grant: Close

Electrophysiology facility for cell phenotyping and drug discovery

Open Date: 2018-01-01

Close Date: 2018-12-31

Grant: Close

Nicotinic receptor structure and function probed with conotoxins

Open Date: 2015-01-01

Close Date: 2019-12-31

Grant: Close

Discovery and development of better pain treatments

Open Date: 2015-01-01

Close Date: 2019-12-31

Grant: Close

Discovery and development of better pain treatments

Open Date: 2015-01-01

Close Date: 2019-12-31

Grant: Close

Alpha-Conotoxin Inhibition of Chronic Visceral Pain

Open Date: 2013-01-01

Close Date: 2015-12-31

Articles (19)

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2022

Collaborators (13)

Maria Novella ROMANELLI

University of Florence

ITALY

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Raymond S. Norton

AUSTRALIA

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Michael Kelso

Professor

University of Wollongong

AUSTRALIA

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Benjamin J. Buckley

University of Wollongong

AUSTRALIA

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Andrea J. Robinson

MONASH UNIVERSITY

AUSTRALIA

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Samuel D. Robinson

University of Queensland

AUSTRALIA

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Jeffrey McArthur

Conjoint Senior Lecturer

University of New South Wales Medicine & Health

AUSTRALIA

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Marie Ranson

University of Wollongong

AUSTRALIA

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Arsalan Yousuf

Lecturer

University of Sydney

AUSTRALIA

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Andrew Hung

Senior Lecturer

RMIT University

AUSTRALIA

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Bankala Krishnarjuna

MONASH UNIVERSITY

AUSTRALIA

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Linlin Ma

Lecturer & Senior Lecturer

Griffith University

AUSTRALIA

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Rocio K. Finol-Urdaneta

University of Wollongong

AUSTRALIA

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David John Adams

Research Interests

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About

Recent Grants

Articles (19)

Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function

GABAB Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell‐Derived Sensory Neurons by Baclofen and α‐Conotoxin Vc1.1

Spider venom peptides with unique fold selectively block Shaker-type potassium channels

Neural control of the heart: intrinsic cardiac ganglion neurons

Molecular determinants of the selectivity and potency of α-conotoxin Vc1.1 for human nicotinic acetylcholine receptors

Dual Antagonism of α9α10 nAChR and GABA<sub>B</sub> Receptor-Coupled Ca<sub>V</sub>2.2 Channels by an Analgesic αO-Conotoxin Analogue.

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain

N-Terminal Capping of the αO-Conotoxin Analogue GeX-2 Improves the Serum Stability and Selectivity toward the Human α9α10 Nicotinic Acetylcholine Receptor

Characterisation of Elevenin-Vc1 from the Venom of <i>Conus victoriae</i>: A Structural Analogue of <i>α</i>-Conotoxins

Nicotinic acetylcholine receptors: Key targets for attenuating neurodegenerative diseases

DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms

Automated Patch Clamp Screening of Amiloride and 5-N,N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor

Brevetoxin versus Brevenal Modulation of Human Nav1 Channels

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: Therapeutic potential of α-conotoxins

<b>Analgesic α</b><b>-Conotoxin Binding Site on the Human GABA<sub>B</sub> Receptor</b>

Mechanism of Action and Structure–Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor

Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor

Collaborators (13)

Maria Novella ROMANELLI

Raymond S. Norton

Michael Kelso

Benjamin J. Buckley

Andrea J. Robinson

Samuel D. Robinson

Jeffrey McArthur

Marie Ranson

Arsalan Yousuf

Andrew Hung

Bankala Krishnarjuna

Linlin Ma

Rocio K. Finol-Urdaneta

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