Mariusz Papp

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Head of Pharmacology Dept and Behavioural Pharmacology Lab/ Professor

Maj Institute of Pharmacology Polish Academy of Sciences

Poland

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About

Dr. Mariusz Papp is a Professor and Head of the Pharmacology Department and Behavioural Pharmacology Lab at the Maj Institute of Pharmacology, Polish Academy of Sciences. His research primarily focuses on the behavioral and pharmacological models of affective disorders, particularly through the investigation of novel antidepressant treatments and their mechanisms of action. Recent publications include studies on the effects of venlafaxine, deep brain stimulation, and the role of biased agonists at the 5-HT 1A receptor in chronic stress models of depression.

Recent Grants

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Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptors, in animal models of depression and treatment-resistant depression

Open Date: 2020-07-01

Close Date:

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Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial prefrontal cortex in an animal model of treatment-resistant depression

Open Date: 2018-02-01

Close Date: 2021-02-01

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The role of inflammation, oxidative and nitrosative stress, tryptophan catabolites pathway and DNA base excision repair in depressive disorder and in acting mechanism of antidepressant drugs in preclinical and clinical in vitro and in vivo studies.

Open Date: 2016-05-01

Close Date:

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Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resistant depression

Open Date: 2016-02-01

Close Date: 2019-02-01

Grant: Close

The effect of imipramine and risperidone on regulation of the chronic mild stressinduced anhedonia and memory impairment by the limbic D1, D2 and D3 receptors in rats.

Open Date: 2014-09-01

Close Date: 2017-04-01

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2021

Collaborators (17)

Piotr Gruca

Institute of Pharmacology

POLAND

Mariusz Papp

Research Interests

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About

Recent Grants

Articles (18)

Efficacy of Venlafaxine and Deep Brain Stimulation Against the Effects of Hippocampal Lesion with Ibotenic Acid in Animals Exposed to the Chronic Mild Stress Model of Depression

The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, like ketamine, elicit rapid-acting antidepressant activity in the rat chronic mild stress model via cortical mechanisms

Chronic N-Acetyl-Cysteine Treatment Enhances the Expression of the Immediate Early Gene <i>Nr4a1</i> in Response to an Acute Challenge in Male Rats: Comparison with the Antidepressant Venlafaxine

Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine

Venlafaxine’s effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization

The 5-HT<sub>1A</sub> receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models.

Models of Affective Illness: Chronic Mild Stress in the Rat.

Early effects of lurasidone treatment in a chronic mild stress model in male rats.

Optogenetic stimulation of transmission from prelimbic cortex to nucleus accumbens core overcomes resistance to venlafaxine in an animal model of treatment-resistant depression.

Involvement of the IL-6 Signaling Pathway in the Anti-Anhedonic Effect of the Antidepressant Agomelatine in the Chronic Mild Stress Model of Depression

Agomelatine Changed the Expression and Methylation Status of Inflammatory Genes in Blood and Brain Structures of Male Wistar Rats after Chronic Mild Stress Procedure

Perspectives for therapy of treatment‐resistant depression

Optogenetic stimulation of medial prefrontal cortex excites GABAergic cells in the nucleus accumbens and hippocampus of Wistar-Kyoto rats exposed to chronic mild stress

Stress Modifies the Expression of Glucocorticoid-Responsive Genes by Acting at Epigenetic Levels in the Rat Prefrontal Cortex: Modulatory Activity of Lurasidone

Chronic mild stress and venlafaxine treatmentwere associated with altered expression level and methylation status of new candidate inflammatory genes in PBMCs and brain structures of wistar rats

The effect of chronic mild stress and escitalopram on the expression and methylation levels of genes involved in the oxidative and nitrosative stresses as well as tryptophan catabolites pathway in the blood and brain structures

Behavioral and molecular effects of the antipsychotic drug blonanserin in the chronic mild stress model

Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response

Collaborators (17)

Piotr Gruca

Marco Andrea Riva

Wojciech B. Solecki

Tomasz Śliwiński

Piotr Czarny

Raffaella Molteni

Fabio Fumagalli

Paulina Wigner

Irena Nalepa

Katarzyna Rafa-Zabłocka

Janusz Szemraj

Grzegorz Hess

Michal Bijak

Nico Mitro

Magdalena Lason

Ewelina Synowiec

Francesca Calabrese

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