Mark John Ingraham Paine

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Liverpool School of Tropical Medicine

United Kingdom

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Mark John Ingraham Paine is a Reader at the Liverpool School of Tropical Medicine in the UK. His research focuses on vector control strategies and resistance mechanisms in malaria mosquitoes, with recent articles addressing topics such as insecticide resistance in Anopheles gambiae and the evaluation of botanical insecticidal synergists. His work aims to improve malaria vector management in diverse settings, particularly in response to ongoing malaria resurgence in Uganda.

Recent Grants

Grant: Close

Preemptive discovery of insecticide cross-resistance mechanisms for next generation malaria control products

Open Date: 2021-02-01

Close Date: 2024-01-31

Grant: Close

Supporting excellence in basic and clinical research: A flow cytometry/sorting and cell imaging platform for the genotypic and phenotypic analysis of Hazard Group 3 pathogens.

Open Date: 2015-01-01

Close Date: 2019-12-31

Articles (21)

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2020

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2020

Collaborators (4)

Álvaro Acosta Serrano

Professor of Vector Biology

University of Notre Dame

UNITED STATES

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Gareth Lycett

Lecturer

Liverpool School of Tropical Medicine

UNITED KINGDOM

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Aitor Casas-Sanchez

Lecturer

Liverpool School of Tropical Medicine

UNITED KINGDOM

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Martin Donnelly

Professor of Evolutionary Genetics

Liverpool School of Tropical Medicine

UNITED KINGDOM

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Mark John Ingraham Paine

Research Interests

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Recent Grants

Articles (21)

Significant variations in tolerance to clothianidin and pirimiphos-methyl in Anopheles gambiae and Anopheles funestus populations during a dramatic malaria resurgence despite sustained indoor residual spraying in Uganda

Impact of Vgsc-1014 mutations on the feeding pattern of Phlebotomus argentipes

Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae

Safety and Efficacy of Incorporating Actellic<sup>®</sup> 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda

Aedes aegypti control in breeding sites through an insecticidal coating with dual effect: Laboratory trials and safety assessment,Control de Aedes aegypti en los sitios de cría mediante un recubrimiento insecticida de efecto dual: ensayos de laboratorio y evaluación de la seguridad

Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers.

Resilience of transfluthrin to oxidative attack by duplicated CYP6P9 variants known to confer pyrethroid resistance in the major malaria mosquito Anopheles funestus.

Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for antimalarial intervention deployment.

Sequential phase I metabolism of pyrethroids by duplicated CYP6P9 variants results in the loss of the terminal benzene moiety and determines resistance in the malaria mosquito Anopheles funestus.

A high-throughput HPLC method for simultaneous quantification of pyrethroid and pyriproxyfen in long-lasting insecticide-treated nets.

Biochemical profiling of functionally expressed CYP6P9 variants of the malaria vector Anopheles funestus with special reference to cytochrome b<sub>5</sub> and its role in pyrethroid and coumarin substrate metabolism.

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes

Improving houses in the Bolivian Chaco increases effectiveness of residual insecticide spraying against infestation with Triatoma infestans, vector of Chagas disease

Indoor residual spraying practices against Triatoma infestans in the Bolivian Chaco: contributing factors to suboptimal insecticide delivery to treated households.

High pyrethroid/DDT resistance in major malaria vector Anopheles coluzzii from Niger-Delta of Nigeria is probably driven by metabolic resistance mechanisms.

Assessing cross-resistance within the pyrethroids in terms of their interactions with key cytochrome P450 enzymes and resistance in vector populations.

High concentrations of membrane-fed ivermectin are required for substantial lethal and sublethal impacts on Aedes aegypti.

Towards understanding transfluthrin efficacy in a pyrethroid-resistant strain of the malaria vector <i>Anopheles funestus</i> with special reference to cytochrome P450-mediated detoxification.

New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids.

Improving the performance of spray operators through monitoring and evaluation of insecticide concentrations of pirimiphos-methyl during indoor residual spraying for malaria control on Bioko Island.

Collaborators (4)

Álvaro Acosta Serrano

Gareth Lycett

Aitor Casas-Sanchez

Martin Donnelly

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