Marko Hyvönen

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University of Cambridge

United Kingdom

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Allosteric inhibitors of liver pyruvate kinase for the treatment of NAFLD

Open Date: 2022-03-01

Close Date: 2024-03-29

Articles (16)

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2025

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2025

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2025

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2024

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2023

An approach for stapled peptide preparation in small scale using recombinant expression of peptide–protein fusions in bacteria. We use this approach to design binders of RAD51, characterise their interaction and demonstrate activity in cells.

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (15)

Paul Dupree

Professor

University of Cambridge

UNITED KINGDOM

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Dessi Malinova

The Queen's University Belfast

UNITED KINGDOM

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Fabrice Gielen

UNITED KINGDOM

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David R. Spring

University of Cambridge

UNITED KINGDOM

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Petra Knaus

Freie Universität Berlin

GERMANY

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Johannes Stigler

Ludwig-Maximilians-Universität München

GERMANY

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Chris Jones

Professor of Childhood Brain Tumour Biology

Institute of Cancer Research

UNITED KINGDOM

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Anassuya Ramachandran

University of Auckland

NEW ZEALAND

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Florian Hollfelder

Professor at University of Cambridge

University of Cambridge

UNITED KINGDOM

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Liuhong Chen

UNITED KINGDOM

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Maximilian Anthony James Harman

UNITED KINGDOM

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Francesca Bottanelli

GERMANY

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Theodora Tryfona

University of Cambridge

UNITED KINGDOM

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Mauro Salvi

Associate Professor

ITALY

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Jessica Downs

Professor

Institute of Cancer Research

UNITED KINGDOM

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Marko Hyvönen

Research Interests

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Recent Grants

Articles (16)

Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators

Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators

Yet another twist to the regulation of the TGF-β family ligands

CK2 Inhibitors Targeting Inside and Outside the Catalytic Box

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase

Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2

A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding

A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase

Functional metagenomic screening identifies an unexpected β-glucuronidase

Development of small cyclic peptides targeting the CK2α/β interface

Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix

A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action

Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation

Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.

The role of pro-domains in human growth factors and cytokines

Collaborators (15)

Paul Dupree

Dessi Malinova

Fabrice Gielen

David R. Spring

Petra Knaus

Johannes Stigler

Chris Jones

Anassuya Ramachandran

Florian Hollfelder

Liuhong Chen

Maximilian Anthony James Harman

Francesca Bottanelli

Theodora Tryfona

Mauro Salvi

Jessica Downs

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