Masashi Narita

[Fully-funded PhD studentship; stipend/funding implied by the title, but no specific amount is stated.] Fully-funded PhD studentship at the University of Cambridge on Understanding the Identity and Function of Tumour-initiating States . The project is based in Prof Masashi Narita’s laboratory, which studies the biology of preneoplastic cell states and how cell identity and plasticity are controlled by the epigenome. The group is interested in how oncogenic and metabolic signalling reshapes chromatin organisation and gene regulation, and how these processes influence cellular fitness, tissue microenvironment, and the emergence of states that suppress or promote tumour development. The PhD project will investigate molecular and epigenetic mechanisms underlying transitions between preneoplastic cell states using diverse in vitro and in vivo models. Depending on the direction developed with the student, the work may include mammalian cell culture, molecular and cell biology, genetic perturbation, imaging, epigenetic and chromatin profiling, early tumorigenesis models, and genomic or single-cell approaches. Collaboration with computational scientists is available for analysis of generated datasets. The lab notes a strong interest in mechanistic biology and experimental approaches to fundamental questions in cancer development. Previous hands-on laboratory research experience is highly desirable. Helpful but non-essential experience includes mammalian cell culture, microscopy, chromatin or epigenetic assays, genetic manipulation, and cancer or ageing model systems. Computational or bioinformatics experience is advantageous but not required. Eligibility is open to both UK and overseas applicants. The advert invites applications from recent graduates or final-year undergraduates who hold or expect to gain a First/Upper Second Class degree, or equivalent, in a relevant subject from a recognised university worldwide. Relevant research experience gained during a Master’s degree or in a laboratory is strongly encouraged. Applications should be submitted through the University Applicant Portal, with a start date of 1 October 2027 selected. The application deadline shown is 16 October 2026 . Referees should be asked to submit references promptly once requested. Further information about the research group and publications is available via the lab website: www.naritalab.com .