Kristina Kirschner

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Reader/ Associate Professor

University of Glasgow

United Kingdom

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About

Kristina Kirschner is a Reader and Associate Professor at the University of Glasgow, UK. Her research focuses on the mechanisms of gene expression regulation, cellular senescence, and the immune landscape in cancer and chronic myeloid leukemia. She has published extensively on topics including hematopoietic stem cell development, clonal competition in cancer, and the functional heterogeneity of senescence.

Recent Grants

Grant: Close

How do senescent stromal cells subvert the treatment response in acute lymphoblastic leukaemia?

Open Date: 2021-11-01

Close Date: 2024-10-31

Grant: Close

Mechanobiology-based medicine

Open Date: 2021-09-30

Close Date: 2022-12-31

Grant: Close

Identifying metabolic vulnerabilities in patients with leukaemia

Open Date: 2021-05-01

Close Date: 2022-04-01

Grant: Close

Dissecting innate immune determinants of severity and resolution in a longitudinal study of COVID-19

Open Date: 2020-11-02

Close Date: 2022-04-30

Grant: Close

What is the role of secondary senescence in disease? Elucidating the role of Notch signalling in secondary senescence

Open Date: 2020-04-01

Close Date: 2022-03-31

Articles (11)

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2025

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2021

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2021

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2021

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2021

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2021

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2020

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2020

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2020

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2020

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2020

Collaborators (15)

Alessandra Nerviani

Clinical Senior Lecturer/Honorary Rheumatology Consultant

UNITED KINGDOM

Kristina Kirschner

Research Interests

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About

Recent Grants

Articles (11)

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

Locus-specific induction of gene expression from heterochromatin loci during cellular senescence

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

BRD4-mediated repression of p53 is a target for combination therapy in AML

Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape

Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development

Induction and transmission of oncogene-induced senescence.

Functional heterogeneity in senescence

Clonality in haematopoietic stem cell ageing.

Collaborators (15)

Alessandra Nerviani

Peter Adams

Pirjo Nummela

Peter Rugg-Gunn

Johanna Englund

Jun-ichi Sakamaki

Shamith Samarajiwa

Arafath Kaja Najumudeen

Lucy MacDonald

Dustin Flanagan

Masako Narita

Domenico Somma

David John Webb

Alexander Raven

Masashi Narita

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