Matthias S. Leisegang

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Goethe University Frankfurt

Germany

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Vascular lncRNAs in the control of the BRG1 remodelling complex (A04)

Open Date: 2019-01-01

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Articles (29)

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Professor of Molecular Cardiology

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt

GERMANY

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Ralf Brandes

Director / Professor / PI

Goethe University Frankfurt

GERMANY

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Andrew H Baker

University of Edinburgh

UNITED KINGDOM

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Verena Linhard

Goethe University Frankfurt

GERMANY

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Andreas Weigert

Associate Professor

Goethe University Frankfurt

GERMANY

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Matthias S. Leisegang

Research Interests

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Recent Grants

Articles (29)

Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents

The relevance of RNA–DNA interactions as regulators of physiological functions

Long Noncoding RNA MIR181A1HG Takes a Proinflammatory Driver’s Seat in Atherosclerosis by Hijacking FOXP1

GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data

Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers

Revealing microRNA regulation in single cells

Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents

The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors

LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses

GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data

RNA-DNA triplexes: molecular mechanisms and functional relevance

Biophysical Investigation of RNA ⋅ DNA : DNA Triple Helix and RNA : DNA Heteroduplex Formation by the lncRNAs MEG3 and Fendrr

Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers

The aging-induced long non-coding RNA<italic> MIRIAL</italic> controls endothelial cell and mitochondrial function

The transaminase-omega-amidase pathway is a redox switch in glutamine metabolism that generates alpha-ketoglutarate

The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.

Detection of statistically robust interactions from diverse RNA-DNA ligation data

The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor

ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth

Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4.

Adhesion of human pathogenic bacteria to endothelial cells is facilitated by fibronectin interaction.

ncOrtho: efficient and reliable identification of miRNA orthologs.

Computational Methods to Study DNA:DNA:RNA Triplex Formation by lncRNAs

Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence

ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2.

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.

A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions.

Collaborators (11)

Ivan Gesteira Costa Filho

Ingo Ebersberger

James Alexander Oo

Ranjan Kumar Maji

Rabea Hinkel

Sven Zukunft

Jaya Krishnan

Ralf Brandes

Andrew H Baker

Verena Linhard

Andreas Weigert

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