Mette Galsgaard Malle

This postdoctoral position at Aarhus University is based in the Department of Chemistry and is part of the ERC Starting Grant-funded project SPARTA . The project focuses on the molecular mechanisms that link protein aggregation and membrane interactions to Parkinson’s disease and broader neurodegenerative disease processes. The successful researcher will work at the interface of single-molecule and single-vesicle imaging , developing and applying advanced fluorescence microscopy approaches to study how α-synuclein oligomers interact with biological membranes. The work is designed to reveal fundamental mechanisms of neurodegeneration and support the development of new strategies for early disease detection. Core research activities include investigating α-synuclein aggregation, probing how membrane composition and physical properties influence protein aggregation and membrane disruption, and creating novel single-vesicle assays for mechanistic studies. The role also includes quantitative image analysis and computational data analysis, making it well suited to someone with strong experimental biophysics and data-driven microscopy expertise. The postdoc will join an interdisciplinary research environment at Aarhus University with collaborations across biophysics, molecular biology, and neuroscience. The group is led by Assistant Professor Mette Galsgaard Malle , whose research centers on single-molecule and single-vesicle imaging to understand molecular interactions and disease mechanisms. The position offers access to state-of-the-art facilities and an international, collaborative setting within the Department of Chemistry. This is a fixed-term research role focused on advancing imaging-based understanding of disease-related membrane biology.