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Mette Galsgaard Malle

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Postdoc in Single-Molecule and Single-Vesicle Imaging of Neurodegenerative Diseases Aarhus University in Denmark

Degree Level

Postdoc

Field of study

Chemistry

Funding

ERC Starting Grant-funded, fixed-term 2-year postdoctoral position; salary and terms according to Danish collective agreement, basic salary steps 4-8.

Deadline

Dec 2, 2026

Country flag

Country

Denmark

University

Aarhus University

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Keywords

Chemistry
Biomedical Engineering
Biophysics
Biology
Parkinson's Disease
Microscopy
Neuropsychology
Neurodegenerative Disease
Physics

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About this position

This postdoctoral position at Aarhus University is based in the Department of Chemistry and is part of the ERC Starting Grant-funded project SPARTA. The project focuses on the molecular mechanisms that link protein aggregation and membrane interactions to Parkinson’s disease and broader neurodegenerative disease processes.

The successful researcher will work at the interface of single-molecule and single-vesicle imaging, developing and applying advanced fluorescence microscopy approaches to study how α-synuclein oligomers interact with biological membranes. The work is designed to reveal fundamental mechanisms of neurodegeneration and support the development of new strategies for early disease detection.

Core research activities include investigating α-synuclein aggregation, probing how membrane composition and physical properties influence protein aggregation and membrane disruption, and creating novel single-vesicle assays for mechanistic studies. The role also includes quantitative image analysis and computational data analysis, making it well suited to someone with strong experimental biophysics and data-driven microscopy expertise.

The postdoc will join an interdisciplinary research environment at Aarhus University with collaborations across biophysics, molecular biology, and neuroscience. The group is led by Assistant Professor Mette Galsgaard Malle, whose research centers on single-molecule and single-vesicle imaging to understand molecular interactions and disease mechanisms. The position offers access to state-of-the-art facilities and an international, collaborative setting within the Department of Chemistry.

This is a fixed-term research role focused on advancing imaging-based understanding of disease-related membrane biology.

Funding details

ERC Starting Grant-funded, fixed-term 2-year postdoctoral position; salary and terms according to Danish collective agreement, basic salary steps 4-8.

What's required

A PhD in nanoscience, biophysics, biochemistry, or a related field is required. Applicants should have experience with single-molecule or single-vesicle fluorescence microscopy, preferably TIRF microscopy, experience with lipid membranes, liposomes, or protein–membrane interactions, strong skills in quantitative image analysis and data processing preferably using Python, experience in scientific publishing, and the ability to work independently and collaboratively in an interdisciplinary research environment. Excellent written and spoken English is required. Experience with α-synuclein, protein aggregation, or neurodegenerative diseases is advantageous but not required.

How to apply

Submit the application through Aarhus University’s recruitment system accessed from the job advertisement. Prepare the application in English and include a CV, degree certificate, complete publication list, statement of future research plans, information about research activities, teaching portfolio, and verified previous teaching experience if any.

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Professors

Assistant Professor at Aarhus University

University Name
Country flag

Denmark

Research Interests

Neuropsychology

Chemistry

Biomedical Engineering

Biology

Biophysics