Michael Boettcher

Juniorprofessor

Martin Luther University Halle-Wittenberg

Germany

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Michael Boettcher is a Juniorprofessor at Martin Luther University Halle-Wittenberg in Germany. His research focuses on pancreatic carcinogenesis, genetic interaction mapping, and the molecular mechanisms underlying metastasis in pancreatic ductal adenocarcinoma. He has extensively contributed to studies involving CRISPR technology and its applications in various cellular contexts, including embryonic stem cells and macrophage viability. His work also explores the implications of genetic mutations in neuroblastoma and the effects of post-translational modifications on cytotoxicity.

Articles (9)

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2025

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2025

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2024

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2022

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2021

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2020

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2020

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2020

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2020

Collaborators (4)

Emmanuelle Charpentier

Scientific and Managing Director/Prof. Dr.

GERMANY

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Michael Hubank

University College London

UNITED KINGDOM

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Hedwig E. Deubzer

GERMANY

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Michiel van Gent

Assistant Professor

Erasmus MC

NETHERLANDS

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Michael Boettcher

Research Interests

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Articles (9)

From Genes to Environment: Elucidating Pancreatic Carcinogenesis Through Genetically Engineered and Risk Factor-Integrated Mouse Models

Evaluation of Cas13d as a tool for genetic interaction mapping.

Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal Adenocarcinoma

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.

Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach.

Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity

High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways.

Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches.

Process for an efficient lentiviral cell transduction

Collaborators (4)

Emmanuelle Charpentier

Michael Hubank

Hedwig E. Deubzer

Michiel van Gent

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