Michael Brockhurst

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The University of Manchester

United Kingdom

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Recent Grants

Grant: Close

Ecological drivers of the evolution of symbiosis

Open Date: 2021-05-01

Close Date: 2024-05-01

Grant: Close

Does CRISPR-Cas immunity limit the effectiveness of phage therapy?

Open Date: 2021-02-01

Close Date: 2024-02-01

Grant: Close

Understanding and predicting the evolution of antibiotic resistance in human infection

Open Date: 2021-02-01

Close Date: 2026-02-01

Grant: Close

Plasmid manipulation of bacterial gene regulatory networks

Open Date: 2018-09-30

Close Date: 2021-09-29

Grant: Close

Determining causal links between interaction type and network structure in microbial communities

Open Date: 2018-09-30

Close Date: 2021-09-29

Articles (20)

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Collaborators (19)

James P. R. Connolly

UNITED KINGDOM

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Katharine Coyte

Sloan Kettering Institute

UNITED STATES

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Steve Paterson

Professor of Genetics

University of Liverpool

UNITED KINGDOM

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Roy Chaudhuri

Lecturer in Bioinformatics

University of Sheffield

UNITED KINGDOM

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Stineke van Houte

University of Exeter

UNITED KINGDOM

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Gregory Hurst

University of Liverpool

UNITED KINGDOM

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Mark Szczelkun

University of Bristol

UNITED KINGDOM

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James Hall

MRC Career Development Fellow / Lecturer

University of Liverpool

UNITED KINGDOM

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Kate Baker

University of Cambridge

UNITED KINGDOM

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Chris Knight

Lecturer

The University of Manchester

UNITED KINGDOM

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Duncan Cameron

The University of Manchester

UNITED KINGDOM

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Danna R Gifford

The University of Manchester

UNITED KINGDOM

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Rebecca Hall

University of Birmingham

UNITED KINGDOM

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Michael Sieber

Max Planck Institute for Evolutionary Biology

GERMANY

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Alan McNally

Professor

University of Birmingham

UNITED KINGDOM

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Andrew P. Beckerman

Professor

University of Sheffield

UNITED KINGDOM

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Katie J. Muddiman

University of Plymouth

UNITED KINGDOM

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Michael Bottery

The University of Manchester

UNITED KINGDOM

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Robert Fagan

Senior Lecturer

University of Sheffield

UNITED KINGDOM

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Michael Brockhurst

Research Interests

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Recent Grants

Articles (20)

Genetic bioaugmentation-mediated bioremediation of terephthalate in soil microcosms using an engineered environmental plasmid

Multiplicity of type 6 secretion system toxins limits the evolution of resistance

Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits

Multidrug resistance plasmids commonly reprogram the expression of metabolic genes in <i>Escherichia coli</i>

Multi-layered genome defences in bacteria.

Genome dynamics across the evolutionary transition to endosymbiosis

A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation

What makes a temperate phage an effective bacterial weapon?

Fitness trade-offs and the origins of endosymbiosis

Plasmids manipulate bacterial behaviour through translational regulatory crosstalk

The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species

Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities

Eco-evolutionary dynamics of experimental Pseudomonas aeruginosa populations under oxidative stress

Horizontal gene transfer and ecological interactions jointly control microbiome stability

Experimental evolution of local adaptation under unidimensional and multidimensional selection

Higher phage virulence accelerates the evolution of host resistance

Why do plasmids manipulate the expression of bacterial phenotypes?

Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation

Functional diversity increases the efficacy of phage combinations

Ecological and evolutionary solutions to the plasmid paradox

Collaborators (19)

James P. R. Connolly

Katharine Coyte

Steve Paterson

Roy Chaudhuri

Stineke van Houte

Gregory Hurst

Mark Szczelkun

James Hall

Kate Baker

Chris Knight

Duncan Cameron

Danna R Gifford

Rebecca Hall

Michael Sieber

Alan McNally

Andrew P. Beckerman

Katie J. Muddiman

Michael Bottery

Robert Fagan

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