Michael Duchen
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Professor of Physiology
United KingdomResearch Interests
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About
Professor Michael Duchen holds a position in the Department of Physiology at University College London, United Kingdom. His research focuses on mitochondrial function, neurodegeneration, and metabolic processes, with recent publications investigating therapeutic targets in mitochondrial ATP synthase, astrocyte dysfunction in Huntington's disease, and neuronal metabolism regulation by Nrf2. He employs innovative techniques such as time-resolved fluorescence and two-photon absorption to explore mitochondrial dynamics and redox status in cellular contexts.
Recent Grants
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Role of microvascular dysfunction in mitochondrial disease: impact of mtDNA mutations on microvascular function as a cause of multisystem mitochondrial disease
Open Date: 2023-08-01
Close Date: 2026-07-01
Grant: Close
Targeting Mitochondrial Dysfunction in iPSc-Derived Neurons from Vici Syndrome Patients: Towards Novel Treatments
Open Date: 2023-03-01
Close Date: 2026-02-01
Grant: Close
causes and consequences of impaired metabolism in GBA1 related Parkinson’s Disease
Open Date: 2021-11-01
Close Date: 2024-10-01
Grant: Close
Exploring novel treatment strategies for primary mitochondrial disease. Collaboration with Nannatherapeutics
Open Date: 2020-09-01
Close Date: 2023-12-01
Grant: Close
Targeting pathways to metabolic dysfunction in Down syndrome-associated Alzheimer’s disease using iPSC derived neurons as a platform for drug discovery
Open Date: 2020-01-01
Close Date: 2023-01-01
Articles (17)
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2023
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2023
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2023
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2022
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2021
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2021
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2021
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2021
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2021
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2021
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2021
Collaborators (11)
Manolis Fanto
Lecturer/Senior Lecturer
King’s College London
Jorge Oliveira
Assistant Professor
University of Porto
Albena Dinkova-Kostova
Academic, Professor (Teaching and Research) of Chemical Biology
University of Dundee
Rodolfo Lavilla
Full professor
University of Barcelona
Charles Quairiaux
University of Geneva
Pablo M. Garcia-Roves
Associate Professor
University of Barcelona
Angus Bain
University College London
Dr Olga Baron
Lecturer/Assistant Professor
Dublin City University
Olivia Gillham
University College London
Robert Pitceathly
University College London
Andreas Neueder
Professor
University Medical Center Hamburg-Eppendorf
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