Michael Ferracane

Associate Professor

University of Redlands

United States

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About

Michael Ferracane is an Associate Professor at the University of Redlands in the United States. His research primarily focuses on the structure-activity relationships of peptide antibiotics, mucin-selective proteases, and opioid receptor pharmacology. Recent articles highlight his contributions to glycoproteomics, structural biology, and the design of therapeutic agents targeting immune checkpoints and cancer-associated mucins.

Articles (10)

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2024

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2024

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2023

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2023

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2022

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2021

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2021

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2020

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University of Washington

UNITED STATES

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Michael Ferracane

Research Interests

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About

Articles (10)

Structure–Activity Relationship Studies of the Peptide Antibiotic Clovibactin

A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences

Classification, structural biology, and applications of mucin domain-targeting proteases

Conformational Constraint between Aromatic Residue Side Chains in the “Message” Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist

The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins

Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine‐seeking behaviour

Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist–Antagonist Following Oral Administration

Collaborators (5)

James Griffin

Mark Lemmon

Keira Mahoney

Stacy Malaker

Nicholas Riley

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