Mark Lemmon

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Alfred Gilman Professor and Co-Director

Yale University School of Medicine

United States

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Recent Grants

Grant: Close

Multiscale Modeling to Optimize Inhibition of Oncogenic ERK Pathway Signaling

Open Date: 2020-02-07

Close Date: 2025-01-31

Grant: Close

Understanding Signaling by Non-Canonical Receptor Tyrosine Kinases

Open Date: 2017-05-01

Close Date: 2022-04-30

Grant: Close

Understanding EGF receptor activation by growth factors and oncogenic mutations

Open Date: 2015-08-18

Close Date: 2020-07-31

Grant: Close

Understanding EGF receptor activation by growth factors and oncogenic mutations

Open Date: 2015-08-18

Close Date: 2025-04-30

Grant: Close

Understanding Wnt signaling through Ror and Ryk family receptor tyrosine kinases

Open Date: 2013-08-01

Close Date: 2017-04-30

Articles (16)

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2023

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (7)

Michael Ferracane

Associate Professor

University of Redlands

UNITED STATES

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Krishna Mudumbi

Yale University

UNITED STATES

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Ravi Radhakrishnan

University of Pennsylvania

UNITED STATES

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Keira Mahoney

Yale University

UNITED STATES

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Stacy Malaker

Associate Professor

Yale University

UNITED STATES

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Linda Z Penn

University Health Network

CANADA

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Stefan Krimmer

Yale University

UNITED STATES

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Mark Lemmon

Research Interests

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Recent Grants

Articles (16)

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes.

Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations.

Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.

Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations

Looking lively: emerging principles of pseudokinase signaling

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias

A Prosperous Future.

Dynamics of protein kinases and pseudokinases by HDX-MS.

Structural basis for ligand reception by anaplastic lymphoma kinase

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.

Phosphatidylserine binding directly regulates TIM-3 function

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.

Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB

Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics

Collaborators (7)

Michael Ferracane

Krishna Mudumbi

Ravi Radhakrishnan

Keira Mahoney

Stacy Malaker

Linda Z Penn

Stefan Krimmer

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