Michael Gotthardt

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W3 (Full) Professor

Max Delbrück Centrum für Molekulare Medizin Berlin Buch

Germany

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About

Michael Gotthardt is a W3 (Full) Professor at the Max Delbrück Centrum für Molekulare Medizin in Berlin Buch, Germany. His research focuses on cardiac health, including the role of RNA-binding proteins in cardiac fibrosis and heart failure, as well as cellular dynamics in skeletal muscle and their implications for cell therapies. He also investigates mechanisms underlying cardiac disease, such as the function of cardiac splicing regulators and mechanotransduction in the heart.

Recent Grants

Grant: Close

CaRNAtion

Open Date: 2016-04-01

Close Date: 2019-03-01

Grant: Close

Regulation of RBM20 expression and activity in cardiac development and disease

Open Date: 2015-01-01

Close Date:

Grant: Close

The Coxsackievirus and Adenovirus Receptor CAR in Cardiac Remodeling

Open Date: 2013-01-01

Close Date:

Grant: Close

A systems and targeted approach to alternative splicing in the developing and diseased heart: Translating basic cell biology to improved cardiac function

Open Date: 2012-01-01

Close Date: 2017-06-30

Grant: Close

Z-disc Titin in Sarcomere Assembly and Mechanotransduction

Open Date: 2010-01-01

Close Date:

Articles (17)

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2023

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2022

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2022

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2022

Collaborators (15)

Maddy Parsons

King’s College London

UNITED KINGDOM

Michael Gotthardt

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About

Recent Grants

Articles (17)

RNA-binding proteins as therapeutic targets in cardiac fibrosis and heart failure

Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells

Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction

Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart.

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

Cardiac splicing as a diagnostic and therapeutic target

A single‐cell RNA labeling strategy for measuring stress response upon tissue dissociation

CAR links hypoxia signaling to improved survival after myocardial infarction.

Disease- and sex-specific differences in patients with heart valve disease: a proteome study.

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.

Correction to: Cardiac sarcomere mechanics in health and disease

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.

HDAC6 modulates myofibril stiffness and diastolic function of the heart.

RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis.

Collaborators (15)

Maddy Parsons

Eric Smith

Claudia Crocini

Maarten M. G. van den Hoogenhof

Sophie Møller

Pia Lundegaard

Christoph Knosalla

Istvan Baczko

Camilla Hansen

Jody Rosenblatt

Wei Guo

Ylva Hellsten

Maria Carmo-Fonseca

Jan Philipp Junker

Sara Wennersten

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