Michael Mitchell

Assistant Professor

University of Pennsylvania

United States

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About

Michael Mitchell is an Assistant Professor at the University of Pennsylvania, USA. His research focuses on lipid nanoparticles and their application in mRNA delivery, cancer therapy, and gene editing. Recent articles include studies on Cas9 protein performance in CFTR repair, high-throughput formulation techniques for lipid nanoparticles, and the engineering of nanoparticles for gynecologic cancer therapy.

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Collaborators (5)

George Burslem

Assistant Professor

University of Pennsylvania

UNITED STATES

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Soyeon Yoo

University of Pennsylvania

UNITED STATES

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Hannah Yamagata

University of Pennsylvania

UNITED STATES

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Andrew Tsourkas

Professor

University of Pennsylvania

UNITED STATES

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Karin Wang

Assistant Professor

Temple University

UNITED STATES

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Michael Mitchell

Research Interests

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About

Articles (29)

Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair

Designer lipids for delivering mRNA to the brain

High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH)

High-throughput platforms for machine learning-guided lipid nanoparticle design

Engineering Nanoparticles for Gynecologic Cancer Therapy

Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma

Ionizable lipid nanoparticles with functionalized PEG-lipids increase retention in the tumor microenvironment

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery

Fine-tuning extracellular fluid viscosity enhances gene delivery

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Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length

Enhancing in situ cancer vaccines using delivery technologies

Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy

OLAH connects fatty acid metabolism to the severity of respiratory viral disease

Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins

Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager

Microfluidic Generation of Diverse Lipid Nanoparticle Libraries

Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager

Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

siRNA Lipid–Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy

In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity

Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta

Rerouting nanoparticles to bone marrow via neutrophil hitchhiking

Rational Design of Nanomedicine for Placental Disorders: Birthing a New Era in Women's Reproductive Health

Exosome-disrupting peptides for cancer immunotherapy

Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

A hydrogel-entrapped live virus immunization

Delivery technologies for women’s health applications

Collaborators (5)

George Burslem

Soyeon Yoo

Hannah Yamagata

Andrew Tsourkas

Karin Wang

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