George Burslem

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Assistant Professor

University of Pennsylvania

United States

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About

George Burslem is an Assistant Professor at the University of Pennsylvania, USA. His research focuses on molecular biology and protein engineering, particularly in the areas of histone deacetylases, influenza virus assembly, and protein degradation mechanisms in cancer. His recent publications explore innovative approaches in protein modification and the functional profiling of proteins, contributing to the advancement of therapeutic strategies and understanding of cellular processes.

Recent Grants

Grant: Open

Unlocking the Chemical Space of Cancer-Associated Perturbations

Open Date: 2022-09-14

Close Date: 2027-08-31

Grant: Open

Metabolic regulation and inhibition of ATP-citrate lyase

Open Date: 2022-04-01

Close Date: 2027-03-31

Grant: Close

Editing Acetylation and Protein Homeostasis

Open Date: 2021-08-01

Close Date: 2026-05-31

Grant: Close

A Protein Degradation Approach for the Treatment of Acute Myeloid Leukemia

Open Date: 2017-07-01

Close Date: 2020-06-30

Articles (19)

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2021

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2021

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2021

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Assistant Professor

UCSF

UNITED STATES

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George Burslem

Research Interests

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Contact this professor

About

Recent Grants

Articles (19)

Intracellular Protein Editing to Enable Incorporation of Non-Canonical Residues into Endogenous Proteins

Class I histone deacetylases catalyze lysine lactylation

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Heavy Metal Meets Protein Homeostasis: Emerging Roles of F‐Box Proteins?

Acetylation: a new target for protein degradation in cancer

Pooled endogenous protein tagging and recruitment for systematic profiling of protein function

Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins

Sortase mediated protein ubiquitination with defined chain length and topology

A Chicken Tapasin ortholog can chaperone empty HLA-B*37:01 molecules independent of other peptide-loading components

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

Regulation of eDHFR-tagged proteins with trimethoprim PROTACs

TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules

Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres

The role of chemical biology in the fight against SARS-CoV-2

Advances and Opportunities in Epigenetic Chemical Biology

Photochemical synthesis of an epigenetic focused tetrahydroquinoline library

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

Collaborators (9)

Erik Procko

Yevgeniy Serebrenik

Andrew McShan

Yi-Wei Chang

Michael Mitchell

Nikolaos Sgourakis

Andrew Tsourkas

Nathaniel Snyder

Emily Goldberg

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