Mikael Rydén

Karolinska Institutet in Stockholm, Sweden is recruiting a PhD student for a project on proteomics and insulin resistance in metabolic disease . The doctoral project will investigate the molecular mechanisms underlying adipocyte insulin resistance and its reversal after bariatric surgery. The research combines mass spectrometry-based proteomics , deep plasma proteomics , metabolomics , multi-omics integration , bioinformatics , quantitative data analysis, and functional studies in human 3D adipocyte models. The work will be carried out in a collaborative environment with Prof. Mikael Rydén, Prof. Yihai Cao, Prof. Volker Lauschke, and their teams. Applicants should have a strong background in biomedicine, molecular biology, biochemistry, biotechnology, metabolism, bioinformatics, or a related field. Experience in proteomics/metabolomics, quantitative data analysis, or metabolic research is especially valued. This is a PhD opening, not a scholarship announcement. The application deadline is 9 October 2026 . Interested candidates should apply via the linked online portal.

A fully funded PhD position is available in Adipocyte Systems Biology at Karolinska Institutet, Stockholm, Sweden (Flemingsberg Campus), supervised by Professor Mikael Rydén in the Rydén & Mejhert Laboratory. The research focuses on how hormonal signals reshape protein organization in human adipocytes, combining subcellular fractionation with mass spectrometry-based proteomics, CRISPR/Cas9 genome editing, live-cell imaging, and biochemical assays. The project aims to integrate discovery proteomics with mechanistic experiments to link protein localization to lipid metabolism, in collaboration with Helmholtz Zentrum München. Ideal candidates should have a Master’s degree in molecular/cellular biology, biochemistry, or a related field, and experience or interest in genome editing, live-cell imaging, or signal transduction. The application deadline is 24 October 2025. For more information or to apply, contact Prof. Mikael Rydén ([email protected]) or HR Partner Anna Heinerö ([email protected]), and visit the application link provided. The position offers an excellent opportunity to work in a leading research environment on cutting-edge topics in adipocyte biology and metabolic regulation.