Mikihiko Naito

Project Professor

University of Tokyo

Japan

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About

Professor Mikihiko Naito is a Project Professor at The University of Tokyo, Japan. His research focuses on the development of innovative therapeutic strategies, particularly in the areas of protein degradation and targeted therapy, as exemplified by his recent articles on decoy oligonucleotides and PROTACs. He explores molecular approaches to overcome drug resistance in cancer treatment, demonstrating a significant commitment to advancing the field of drug development.

Articles (12)

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

Collaborators (2)

Yasushi Saeki

Professor

University of Tokyo

JAPAN

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Nobumichi Ohoka

National Institute of Health Sciences

JAPAN

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Mikihiko Naito

Research Interests

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Articles (12)

cIAP1-based degraders induce degradation via branched ubiquitin architectures

Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor

Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands

Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)

Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors

Current Status of Oligonucleotide-Based Protein Degraders

Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3

Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor

Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein

Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling

Development of a potent small‐molecule degrader against oncogenic <scp> BRAF <sup>V600E</sup> </scp> protein that evades paradoxical <scp>MAPK</scp> activation

Targeted protein degradation and drug discovery

Collaborators (2)

Yasushi Saeki

Nobumichi Ohoka

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