Yasushi Saeki

Professor

University of Tokyo

Japan

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About

Yasushi Saeki is a Professor at The University of Tokyo, Japan. His research encompasses the fields of protein degradation, ubiquitin signaling pathways, and the interactions of proteins within cellular environments. Recent publications include studies on the regulatory mechanisms of proteasomal degradation and the development of selective probes for evaluating protein stability in live cells.

Articles (16)

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2025

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2025

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2025

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2025

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2024

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2024

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (15)

Fuminori Tokunaga

Professor

Osaka University

JAPAN

Yasushi Saeki

Research Interests

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Articles (16)

Substrate structure determines p97- and RAD23A/B-mediated proteasomal degradation in human cells

Adaptor-Specific Peptide Inhibitors of the Ubiquitin-Chain-Dependent Unfolding Activity of the Human p97(VCP)–UFD1–NPL4 Complex

Combinatorial ubiquitin code degrades deubiquitylation-protected substrates

TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells

Intrinsic signaling pathways modulate targeted protein degradation

USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes

cIAP1-based degraders induce degradation via branched ubiquitin architectures

The TGN/EE SNARE protein SYP61 and the ubiquitin ligase ATL31 cooperatively regulate plant responses to carbon/nitrogen conditions in Arabidopsis

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via in Silico Design

RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells

The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC

A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

Collaborators (15)

Fuminori Tokunaga

Yasuhiro Fuseya

Katsuhiro Sasaki

Akihito Inoko

Toshiaki Fukushima

Takuya Tomita

Toshikazu Ushijima

Minsoo Kim

Tony Ly

Kenta Moriwaki

Mikihiko Naito

Kei Okatsu

Yukiko Yoshida

Shigetsugu Hatakeyama

Yoichiro Fukao

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