Monika Hegi

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Prof, PhD

Lausanne University Hospital

Switzerland

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Recent Grants

Grant: Open

Epigenetic landscape of gliomas and their implications for tumor biology and treatment of cancer

Open Date: 2023-05-01

Close Date: 2027-04-30

Grant: Close

Prediction of the natural clinical course of IDHmt low grade glioma to guide treatment decisions

Open Date: 2022-08-01

Close Date: 2024-07-01

Grant: Close

MGMT methylation score for predicting benefit from TMZ in patients with IDHmt low grade glioma to guide treatment decisions

Open Date: 2020-01-01

Close Date: 2022-06-01

Grant: Close

Targeting the epigenome of glioblastoma

Open Date: 2019-09-01

Close Date: 2022-01-01

Grant: Close

Epigenetic landscape of gliomas and their implications for tumor biology and treatment of cancer

Open Date: 2019-02-01

Close Date: 2023-01-31

Articles (15)

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2024

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2021

Collaborators (14)

Martin van den Bent

Erasmus University Rotterdam

NETHERLANDS

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Sabina Berezowska

Associate Professor, Médecin cheffe

SWITZERLAND

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Pieter Wesseling

Amsterdam University Medical Centers

NETHERLANDS

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Arnaud Comment

University of Cambridge

UNITED KINGDOM

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Gabriel Fernández Calvo

Full Professor

University of Castilla-La Mancha

SPAIN

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Alice Scarpa

University of Bonn

GERMANY

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Pim French

Assoc Prof

Erasmus MC

NETHERLANDS

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Bernard Lanz

Researcher / Lecturer

École Polytechnique Fédérale de Lausanne

SWITZERLAND

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Bernd Kaina

University Medical Center of the Johannes Gutenberg University Mainz

GERMANY

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Bastiaan Tops

Head of laboratory for childhood cancer pathology

Prinses Máxima Centrum voor Kinderoncologie

NETHERLANDS

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Bjarne Winther Kristensen

Clinical professor (chair)

University of Copenhagen

DENMARK

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marco alloisio

Humanitas University

ITALY

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Felix Sahm

University Hospital Heidelberg

GERMANY

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Luca Bertero

Associate professor of Pathology

University of Turin

ITALY

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Monika Hegi

Research Interests

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Recent Grants

Articles (15)

No benefit from TMZ treatment in glioblastoma with truly unmethylated MGMT promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly glioblastoma patients

Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms

Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors

Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG

Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline

EANO guideline on rational molecular testing of gliomas, glioneuronal and neuronal tumors in adults for targeted therapy selection

Long-term survival with IDH wildtype glioblastoma

The local microenvironment drives activation of neutrophils in human brain tumors

Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells

DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients

Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma

Collaborators (14)

Martin van den Bent

Sabina Berezowska

Pieter Wesseling

Arnaud Comment

Gabriel Fernández Calvo

Alice Scarpa

Pim French

Bernard Lanz

Bernd Kaina

Bastiaan Tops

Bjarne Winther Kristensen

marco alloisio

Felix Sahm

Luca Bertero

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