Natalia Porębska

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Assistant professor

University of Wrocław

Poland

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About

Natalia Porębska is an Assistant Professor at the University of Wrocław in Poland. Her research areas focus on the development of protein-drug conjugates, cancer immunotherapy, and molecular imaging, as evidenced by her recent publications on HER2-targeted therapies and galectin-specific nanobodies. Her work also explores the biochemical mechanisms of growth factor signaling and endocytosis, contributing to advancements in drug delivery systems and therapeutic strategies for cancer treatment.

Recent Grants

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Highly-internalizing intrinsically fluorescent oligomeric cytotoxic conjugate targeting breast cancer cells overproducing HER2

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Articles (10)

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2025

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2024

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2024

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2024

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2024

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2024

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2023

Collaborators (4)

Łukasz Opalinski

Assistant professor (adjunct)

Wroclaw University of Science and Technology

POLAND

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Nicolas Doucet

Professor

CANADA

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Martyna Biaduń

University of Wrocław

POLAND

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Adam Pomorski

Associate professor

University of Wrocław

POLAND

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Natalia Porębska

Research Interests

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About

Recent Grants

Articles (10)

Innately Fluorescent Tetravalent Cytotoxic Conjugate TetraF<sub>HER2</sub>-vcMMAE Engages Aggregation-Dependent Endocytosis of HER2 for Enhanced Intracellular Drug Delivery

Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor

Development of Galectin-7-Specific Nanobodies: Implications for Immunotherapy and Molecular Imaging in Cancer

Thermostable phenylacetic acid degradation protein TtPaaI from Thermus thermophilus as a scaffold for tetravalent display of proteins

Engineered intrinsically fluorescent galectin-8 variants with altered valency, ligand recognition and biological activity

The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex

Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs

The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis

Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2

Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

Collaborators (4)

Łukasz Opalinski

Nicolas Doucet

Martyna Biaduń

Adam Pomorski

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