Łukasz Opalinski

Assistant professor (adjunct)

Wroclaw University of Science and Technology

Poland

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Łukasz Opalinski is an Assistant Professor (adjunct) at the University of Wroclaw, Poland. His research encompasses areas including cytotoxic conjugates for enhanced drug delivery, recombinant protein purification, and the mechanisms of fibroblast growth factor signaling. Recent articles highlight his work on the unique properties of FGF12 and its roles in cellular processes, as well as novel strategies for targeting cancer cells via receptor-mediated approaches.

Articles (18)

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2025

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2024

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2021

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2021

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2021

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2020

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2020

Collaborators (7)

Daniel Krowarsch

University of Wrocław

POLAND

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Malgorzata Zakrzewska

University of Wrocław

POLAND

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Martyna Biaduń

University of Wrocław

POLAND

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Jakub Rzeszótko

Max Planck Institute of Molecular Cell Biology and Genetics

GERMANY

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Natalia Porębska

Assistant professor

University of Wrocław

POLAND

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Adam Pomorski

Associate professor

University of Wrocław

POLAND

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Jacek Otlewski

Wroclaw University of Science and Technology

POLAND

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Łukasz Opalinski

Research Interests

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Articles (18)

Innately Fluorescent Tetravalent Cytotoxic Conjugate TetraF<sub>HER2</sub>-vcMMAE Engages Aggregation-Dependent Endocytosis of HER2 for Enhanced Intracellular Drug Delivery

Thermostable phenylacetic acid degradation protein TtPaaI from Thermus thermophilus as a scaffold for tetravalent display of proteins

Production and purification of recombinant long protein isoforms of FGF11 subfamily

Uncovering key steps in FGF12 cellular release reveals a common mechanism for unconventional FGF protein secretion

FGF12: biology and function

FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response

Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling

FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance

FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs

Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers

Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1

Galectins as modulators of receptor tyrosine kinases signaling in health and disease

Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

Collaborators (7)

Daniel Krowarsch

Malgorzata Zakrzewska

Martyna Biaduń

Jakub Rzeszótko

Natalia Porębska

Adam Pomorski

Jacek Otlewski

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