Natalie Theodoulou

University of Manchester

United Kingdom

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Articles (5)

Year:

2024

Year:

2022

Year:

2022

Year:

2021

Year:

2020

Collaborators (4)

Rosa Ellen Cookson

Tessera Therapeutics

UNITED KINGDOM

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Emmanuel Demont

Head of Medicinal Chemistry

UNITED KINGDOM

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Philip Humphreys

GlaxoSmithKline

UNITED KINGDOM

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Craig Jamieson

Professor

University Of Strathclyde

UNITED KINGDOM

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Natalie Theodoulou

Research Interests

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Articles (5)

Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787

Identification and optimization of a ligand-efficient benzoazepinone bromodomain and extra terminal (BET) family acetyl-lysine mimetic into the oral candidate quality molecule I-BET432

Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate

Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors

Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains

Collaborators (4)

Rosa Ellen Cookson

Emmanuel Demont

Philip Humphreys

Craig Jamieson

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