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Nicholas Caron

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Research Associate

The University of British Columbia

Canada

Research Interests

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Recent Grants

Grant: Open

Multi-omic biomarker discovery for Huntington disease

Open Date: 2025-03-01

Close Date: 2027-02-01

Grant: Close

Delivery of mutant HTT lowering antisense oligonucleotides across the blood brain barrier for Huntington disease

Open Date: 2019-07-01

Close Date: 2022-06-01

Grant: Close

Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity

Open Date: 2019-04-01

Close Date:

Articles (9)

Year:

2025

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2025

Year:

2025

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2024

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2024

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2024

Year:

2023

Year:

2023

Year:

2023

Collaborators (7)

Nicole Déglon

Associate Professor

Lausanne University Hospital (CHUV)

SWITZERLAND

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Maciej Figiel

Full Professor, Principal Investigator

Institute of Bioorganic Chemistry Polish Academy of Sciences

POLAND

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Lauren Byrne

University College London

UNITED KINGDOM

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Michael R. Hayden

Killam Professor

The University of British Columbia

CANADA

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Dale Martin

Associate Professor

University of Waterloo

CANADA

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Agnieszka Fiszer

Head of Department

Institute of Bioorganic Chemistry Polish Academy of Sciences

POLAND

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Douglas Langbehn

Professor

Iowa State University

UNITED STATES

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Nicholas Caron

Research Interests

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Recent Grants

Articles (9)

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification

Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease

Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models

Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease.

Limitations of dual-sgRNA CRISPR strategies for the treatment of CNS genetic disorders

Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks

Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models

Collaborators (7)

Nicole Déglon

Maciej Figiel

Lauren Byrne

Michael R. Hayden

Dale Martin

Agnieszka Fiszer

Douglas Langbehn

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