Nikolaos Sgourakis

Associate Professor

University of Pennsylvania

United States

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Nikolaos Sgourakis is an Associate Professor at the University of Pennsylvania, USA. His research focuses on the structural and functional dynamics of MHC-I:TCR interactions, antigen presentation mechanisms, and the precision of DNA proofreading by Cas9. He has contributed to advancements in understanding peptide/HLA complexes and their implications for T cell recognition through numerous published articles.

Articles (16)

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UNITED STATES

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Nikolaos Sgourakis

Research Interests

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Articles (16)

CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens

Solution mapping of MHC-I:TCR interactions using a minimalistic protein system

Dynamic sampling of a surveillance state enables DNA proofreading by Cas9

A Chicken Tapasin ortholog can chaperone empty HLA-B*37:01 molecules independent of other peptide-loading components

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes

Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition

HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes

Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation

TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules

Dynamics of MHC-I molecules in the antigen processing and presentation pathway

TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap

Backbone-independent NMR resonance assignments of methyl probes in large proteins

Nearest-neighbor NMR spectroscopy: categorizing spectral peaks by their adjacent nuclei

Computational design of closely related proteins that adopt two well-defined but structurally divergent folds

Collaborators (6)

Erik Procko

Jiansheng Jiang

Andrew McShan

George Burslem

Gerhard Wagner

Vera Moiseenkova-Bell

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