Ola Rominiyi

University of Sheffield

United Kingdom

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Articles (11)

Glioblastoma is an aggressive, incurable brain cancer with poor five-year survival rates of around 13% despite multimodal treatment with surgery, DNA-damaging chemoradiotherapy and the recent addition of Tumour Treating Fields (TTFields). As such, there is an urgent need to improve our current understanding of cellular responses to TTFields using more clinically and surgically relevant models, which reflect the profound spatial heterogeneity within glioblastoma, and leverage these biological insights to inform the rational design of more effective therapeutic strategies incorporating TTFields. We have recently reported the use of preclinical TTFields using the inovitroTM system within 2D glioma stem-like cell (GSC) models and demonstrated significant cytotoxicity enhancement when co-applied with a range of therapeutically approved and preclinical DNA damage response inhibitors (DDRi) and chemoradiotherapy. Here we report the development and optimisation of preclinical TTFields delivery within more clinically relevant 3D scaffold-based primary GSC models of spatial heterogeneity, and highlight some initial enhancement of TTFields potency with temozolomide and clinically approved PARP inhibitors (PARPi). These studies, therefore, represent an important platform for further preclinical assessment of TTFields-based therapeutic strategies within clinically relevant 3D GSC models, aimed towards accelerating clinical trial implementation and the ultimate goal of improving the persistently dire survival rates for these patients.

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2024

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2021

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2021

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2021

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2021

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (74)

Hisham Marwan

Associate Professor

University of Texas Medical Branch

UNITED STATES

Ola Rominiyi

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Articles (11)

Development and Optimisation of Tumour Treating Fields (TTFields) Delivery within 3D Primary Glioma Stem Cell-like Models of Spatial Heterogeneity

Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic

Identification and validation of ERK5 as a DNA damage modulating drug target in glioblastoma

CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service.

Correction: Tumour treating fields therapy for glioblastoma: current advances and future directions.

DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies.

O2: TOWARDS A LIVING BIOBANK OF SURGICALLY-RELEVANT 3-DIMENSIONAL GLIOBLASTOMA STEM CELL MODELS TO EVALUATE NOVEL THERAPEUTICS AND INTERROGATE INTRATUMOURAL HETEROGENEITY

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Delaying surgery for patients with a previous SARS-CoV-2 infection.

COVD-15. COVIDNEUROONC: A UK MULTI-CENTRE, PROSPECTIVE COHORT STUDY OF THE IMPACT OF THE COVID-19 PANDEMIC ON THE NEURO-ONCOLOGY SERVICE

Collaborators (74)

Hisham Marwan

Jana Dziakova

Simon Thomson

George Fowler

Jacobo Trebol

Ladislao Cayetano Paniagua

Mohamed Elshaer

Panteleimon Vassiliu

Mark Corrigan

Pieter Steinkamp

Thomas Curl-Roper

JIANNIS HAJIIOANNOU

Brenda F Narice

Pierpaolo Sileri

BALTASAR PÉREZ-SABORIDO

Ayush Joshi

Stuart Smith

Satheesh prabhu

Alfredo Vivas Lopez

Davide Citterio

Ching Wan Chan

Vasileios Papadopoulos

Callum G. Jones

Ruth A Benson

Jason C. Fleming

Luca Nespoli

Shafaque Shaikh

Amanda Caroline Dawson

Antonio D'URSO

Niraj Gusani

David Miller

Massimiliano Fambrini

Antonios Gklavas

Kristin Colling

VALERIA TONINI

Emma Whitehall

Cristobal Langdon

Louis Brown

Luigi Rolli

Erik Omling

Raphael Clifford

Rodrigo Arrangoiz

Marta Costa

Khalid Ahmed

Saurabh Sinha

anastasios kanatas

Rustom Manecksha

Matthieu Peycelon

Stefano Scabini

Gemma Owens

OLGA MATEO-SIERRA

Michael Grechenig

GIAN MARCO PRUCHER

Stephen Brown

Gayle Ackerman DiLalla

Victoria Wykes

Simon Burg

Jaroslav Presl

Mohamed Bekheit

Elaine Leung

Christian Praetorius

Basaran Bahadir Kocer

Gavin Murphy