Jason C. Fleming

United Kingdom

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Articles (20)

Year:

2024

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2024

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2024

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2024

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2023

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2023

Tensin 1 was originally described as a focal adhesion adaptor protein, playing a role in extracellular matrix and cytoskeletal interactions. Three other Tensin proteins were subsequently discovered, and the family was grouped as Tensin. It is now recognized that these proteins interact with multiple cell signalling cascades that are implicated in tumorigenesis. To understand the role of Tensin 1–3 in neoplasia, current molecular evidence is categorized by the hallmarks of cancer model. Additionally, clinical data involving Tensin 1–3 are reviewed to investigate the correlation between cellular effects and clinical phenotype. Tensin proteins commonly interact with the tumour suppressor, DLC1. The ability of Tensin to promote tumour progression is directly correlated with DLC1 expression. Members of the Tensin family appear to have tumour subtype‐dependent effects on oncogenesis; despite numerous data evidencing a tumour suppressor role for Tensin 2, association of Tensins 1–3 with an oncogenic role notably in colorectal carcinoma and pancreatic ductal adenocarcinoma is of potential clinical relevance. The complex interplay between these focal adhesion adaptor proteins and signalling pathways are discussed to provide an up to date review of their role in cancer biology.

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2021

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2021

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2021

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2021

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2021

Year:

2020

Year:

2020

Collaborators (60)

Hisham Marwan

Associate Professor

University of Texas Medical Branch

UNITED STATES

Jason C. Fleming

Research Interests

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Articles (20)

Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.

The European Network for Sinonasal Cancer Research (EUSICA) - A pan-European initiative targeting a group of orphan tumours.

Development of a head and neck lymphoedema specific quality of life tool: The Comprehensive Assessment of Lymphoedema Impact in the Head and Neck (CALI-HaN)

Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis.

Determination of Flap Survival Isolated From Wound Bed Vasculature Using a Murine Axial Flap Model

The molecular and clinical role of Tensin 1/2/3 in cancer

Predictors of non‐functional larynx following (chemo)radiotherapy for locally advanced laryngeal cancer

Head and neck lymphedema and quality of life: the patient perspective.

A review of unplanned admissions in head and neck cancer patients undergoing oncological treatment.

Gastrostomy dependence following pharyngolaryngectomy: The effect of preoperative tube insertion

International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System

Management of sinonasal cancers: Survey of UK practice and literature overview

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic

Orbital exenteration and reconstruction in a tertiary UK institution: a 5-year experience

A Multicentre UK Study of Outcomes for Locally Advanced Sinonasal Squamous Cell Carcinoma Treated with Adjuvant or Definitive Intensity-modulated Radiotherapy.

Utility of intraoperative frozen sections of thyroid tissue in the age of molecular testing.

Post‐Treatment Head and Neck Cancer Care: National Audit and Analysis of Current Practice in the United Kingdom

CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer

Head and neck cancer surgery during the COVID‐19 pandemic: An international, multicenter, observational cohort study

Collaborators (60)

Hisham Marwan

Jana Dziakova

Carissa Thomas

Ladislao Cayetano Paniagua

Hiroshi Yonekura

Mohamed Elshaer

Andreas Älgå

Thomas Curl-Roper

ludi smeele

Brenda F Narice

Luca Bruschini

Gareth J. Thomas

Ola Rominiyi

Satheesh prabhu

Christopher Hanley

Jasper Stijns

Ebba K Lindqvist

Luca Nespoli

Alexandros Charalabopoulos

Emma Howie

Sajid Sainuddin

CHRISTOS KONTOVOUNISIOS

Nina Glass

Massimiliano Fambrini

Florence Cook

Hemant M Kocher

Mary Gemma Cherry

Luigi Rolli

Christoph Grimm

Joshua P Totty

Georg Singer

Gemma Mancebo Moreno

anastasios kanatas

Mark Gormley

Teresa Guerrero Urbano

Matthew Cooper

Lene Hjerrild Iversen

Fadi Issa

Warwick J Teague

Marianne Hollyman

Mahmoud Hafez

Tom Abbott

Simon Lammy

Luis Joaquín García Flórez

GIAN MARCO PRUCHER

Gayle Ackerman DiLalla

Robbie Woods

Mohamed Otify

Dale Vimalachandran

Julio Domenech Fernández

Mohamed Bekheit

Christian Praetorius

Stuart C Winter

Gerardo Petruzzi