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Paola Vacca

Has grant

Head of research unit

Ospedale Pediatrico Bambino Gesù

Italy

Research Interests

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Professors in Italy Professors in Immunology Immunology professors in Italy

Recent Grants

Grant: Close

Arming NK cells with innovative chimeric activating immunocheckpoints to target suppressive tumor microenvironment

Open Date: 2023-01-02

Close Date: 2025-04-01

Grant: Close

Sviluppo di cellule Natural Killer geneticamente modificate capaci di contrastare l’effetto inibitorio del microambiente tumorale

Open Date: 2022-01-01

Close Date: 2022-12-01

Grant: Close

Ruolo in vivo delle cellule mieloidi soppressorie nel microambiente tumorale e nel trapianto di cellule staminali ematopoietiche.

Open Date: 2021-01-01

Close Date: 2021-12-01

Grant: Close

Ruolo delle cellule mieloidi con funzione immunosoppressoria (MDSC) nel microambiente tumorale

Open Date: 2020-01-01

Close Date: 2020-12-01

Grant: Close

Ruolo delle cellule mieloidi con funzione immunosoppressoria (MDSC) nel trapianto aploidentico

Open Date: 2019-01-01

Close Date: 2019-12-01

Articles (20)

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Collaborators (5)

Roberto Ria

Professore Ordinario

ITALY

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Giuseppe Sciumè

Sapienza University of Rome

ITALY

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Ignazio Caruana

Group Leader - Scientific Research

University Hospital Würzburg

GERMANY

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Manuela Antonioli

Associate Professor

University of Rome Tor Vergata

ITALY

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Roberta Nardacci

Professore Associato (BIO-13)

Saint Camillus International University of Health Sciences

ITALY

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Paola Vacca

Research Interests

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Recent Grants

Articles (20)

The transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15Rα chain

Experimental protocol for ocular surface immune cell isolation and functional analysis using Schirmer test strips

Myeloid-Derived Suppressor Cells in Cancer: Metabolic Reprogramming, Immune Crosstalk, and Therapeutic Targeting

Correction: Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells (Frontiers in Cellular and Infection Microbiology, (2025), 15, (1612198), 10.3389/fcimb.2025.1612198)

IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells

ILC2s and their immune checkpoints in the antitumor response

Protocol to isolate, expand, and activate human type 2 innate lymphoid cells to study immune checkpoint function

Progressive NK Cell Dysfunction and ILC Imbalance Favor Immune Evasion in Multiple Myeloma

Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma

Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma (vol 44, 185, 2025)

Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells

Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment

Immunophenotyping in Vernal Keratoconjunctivitis: Schirmer Test for Therapy Response Prediction

Innate Lymphoid Cell Phenotypic and Functional Alterations in Patients With Systemic Juvenile Idiopathic Arthritis

Progressive NK cell dysfunction and ILC imbalance as drivers of immune evasion in multiple myeloma.

T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes

Manipulating the tumor immune microenvironment to improve cancer immunotherapy: IGF1R, a promising target

Myeloid-derived suppressor cells: Identification and function

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Collaborators (5)

Roberto Ria

Giuseppe Sciumè

Ignazio Caruana

Manuela Antonioli

Roberta Nardacci

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