Patricia Sanchez-Baracaldo

Project Overview: This PhD opportunity at the University of Bristol, School of Geographical Sciences, explores how cyanobacteria revolutionized Earth's surface environments by developing metabolic strategies to acquire scarce nutrients, particularly phosphorus and nitrogen. These innovations enabled cyanobacteria to produce the first biogenic oxygen and shaped the co-evolution of life and Earth's biogeochemical cycles over nearly three billion years. Research Focus: The project aims to resolve the evolutionary timing, genomic origins, and ecological drivers of nutrient-acquisition systems in cyanobacteria. Using large-scale comparative genomics and phylogenomic approaches, the student will reconstruct the evolutionary history of genes and operons involved in phosphorus and nitrogen uptake, identify patterns of gene gain, loss, and lateral gene transfer, and assess the impact of these innovations on biogeochemical cycling in ancient and modern aquatic environments. Methodology: The research will involve reconstructing the evolutionary history of key metabolic pathways (e.g., pstSCAB, pho regulon, phosphonate pathways for phosphorus; nitrate/nitrite transporters, ammonium uptake, cyanide degradation for nitrogen), analyzing gene transfer events, and modeling the influence of genomic innovations on nutrient limitation in Proterozoic and contemporary ecosystems. The student will have opportunities to generate new datasets and develop novel phylogenomic tools. Training & Skills: The supervisory team, led by Professor Patricia Sanchez-Baracaldo and co-supervised by Dr. Lewis Alcott, Dr. Fanny Monteiro, and Dr. Joanne Boden, will provide tailored training in comparative genomics, molecular evolution, phylogenetics, and computer programming (e.g., Shell Scripting, R, Python). These skills are highly transferrable and valuable for careers in evolutionary biology, microbial genomics, and bioinformatics. Funding: The Bristol Postgraduate Research Scholarship covers full tuition fees, a UKRI stipend (£20,780 for 2025/26), and up to £2,100 per year for research expenses, for a total registration period of 4 years. The project begins in September 2026. Eligibility: Applicants should have a strong academic background in biology, earth sciences, environmental science, or related fields. Programming skills in C/C++, Python, R, or Matlab are advantageous. Interest in evolutionary biology, genomics, and biogeochemical cycles is essential. Application Process: Apply to the 'Geography (PhD)' programme at the University of Bristol. For informal enquiries, contact Professor Patricia Sanchez-Baracaldo at [email protected]. The application deadline is 19th January 2026. Useful Links: Scholarship Information | Postgraduate Courses | Application Portal