Patrick Derksen

PRINCIPAL INVESTIGATOR/PROFESSOR, PHD

Universitair Medisch Centrum Utrecht

Netherlands

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Professor Patrick Derksen is a Principal Investigator at Universitair Medisch Centrum Utrecht, Netherlands. His research primarily focuses on cancer biology, with recent work exploring transcriptional invasion signatures, prognostic classifiers for head and neck cancer, and the mechanosensitivity of talin-1 in various cancer types. He also investigates diagnostic and treatment strategies for invasive lobular breast cancer and the role of E-cadherin during metastasis.

Articles (13)

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (11)

Ben Goult

Professor of Biochemistry

University of Kent

UNITED KINGDOM

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Christine Desmedt

Head of Laboratory for Translational Breast Cancer Research

KU Leuven

BELGIUM

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Manasa Chanduri

Yale University

UNITED STATES

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Antoine A. Khalil

Assistant Professor/PhD

UMC Utrecht

NETHERLANDS

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Sandra Tavares

NETHERLANDS

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martin schwartz

Professor

Yale University School of Medicine

UNITED STATES

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Amanda Fitzpatrick

Clinical Senior Lecturer

King's College London

UNITED KINGDOM

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Natalie ter Hoeve

UMC Utrecht

NETHERLANDS

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Jan Mol

Associate Professor

Utrecht University

NETHERLANDS

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Wim Waelput

Vrije Universiteit Brussel

BELGIUM

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Nalan Liv

Assistant Professor

University Medical Center Groningen

NETHERLANDS

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Patrick Derksen

Research Interests

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Articles (13)

Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer

Combined spatial Keratin expression profiles at the invasive front represent a prognostic classifier for head and neck cancer

TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice

Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type

Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis.

Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer.

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer.

FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer.

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment.

Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma.

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions.

Collaborators (11)

Ben Goult

Christine Desmedt

Manasa Chanduri

Antoine A. Khalil

Sandra Tavares

martin schwartz

Amanda Fitzpatrick

Natalie ter Hoeve

Jan Mol

Wim Waelput

Nalan Liv

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