Patrick J. Bednarski

Professor

University of Greifswald

Germany

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About

Patrick J. Bednarski is a Professor at the University of Greifswald, Germany. His research focuses on various aspects of medicinal chemistry, including cytotoxicity and the development of drugs with improved metabolic profiles. Recent publications highlight his work on the structure-activity relationships of novel compounds and their potential therapeutic applications in cancer and other diseases.

Articles (20)

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2025

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2020

Collaborators (11)

Daniel Baecker

Freie Universität Berlin

GERMANY

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Andreas Link

Full professor

Universität Greifswald Mathematisch-Naturwissenschaftliche Fakultät

GERMANY

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Tomasz Plech

Medical University of Lublin

POLAND

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Elias Eger

GERMANY

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Lukas Schulig

University of Greifswald

GERMANY

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Louis Schmidt

University of Greifswald

GERMANY

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Małgorzata Szczesio

Lodz University of Technology

POLAND

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Carola Schulzke

Chair/Prof. Dr.

University of Greifswald

GERMANY

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Anita Kornicka

Medical University of Gdansk

POLAND

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Maria Gdaniec

Professor

Uniwersytet im Adama Mickiewicza w Poznaniu Wydział Chemii

POLAND

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Izabela Korona-Glowniak

associate professor/Ph.D.

Medical University of Lublin

POLAND

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Patrick J. Bednarski

Research Interests

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Articles (20)

New KV7.2/3 Channel Activators Exhibit Superior Toxicity and Metabolic Profiles to Flupirtine and Demonstrate Promising In Vivo Analgesic Effects

Lead Optimization of Positive Allosteric KV7.2/3 Channel Modulators toward Improved Balance of Lipophilicity and Aqueous Solubility

Structure‐activity‐relationships of the Stability of Six Pentathiepins Towards Glutathione: Possible Correlations with Biological Activities

Cytotoxicity of Atropisomeric [1,1′‐Binaphthalene]‐2,2′‐Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure–Activity Relationships, and Mechanism

Crystallographic and Electroanalytical Analyses of Fexinidazole and Its Major Metabolites

Dose-Dependent Concentration and Penetration Depth of Cisplatin in Human Lung Tissue During Hyperthermic Exposure

Investigation of TGF‐α‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

A graphite furnace‐atomic absorption spectrometry‐based rubidium efflux assay for screening activators of the Kv7.2/3 channel

Liposomal formulation of model pentathiepin improves solubility and stability toward glutathione while preserving anticancer activity

Copper(II) Complexes with 1-(Isoquinolin-3-yl)heteroalkyl-2-ones: Synthesis, Structure and Evaluation of Anticancer, Antimicrobial and Antioxidant Potential

Synthesis, Structure and Cytotoxic Properties of Copper(II) Complexes of 2-Iminocoumarins Bearing a 1,3,5-Triazine or Benzoxazole/Benzothiazole Moiety

Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation

Modifications of the Triaminoaryl Metabophore of Flupirtine and Retigabine Aimed at Avoiding Quinone Diimine Formation

Correlation Analysis of Protein Expression of 10 HDAC/Sirtuin Isoenzymes with Sensitivities of 23 Anticancer Drugs in 17 Cancer Cell Lines and Potentiation of Drug Activity by Co-Treatment with HDAC Inhibitors

Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer; Part 3: Selective Cytotoxic Activity of 22 Plants against Human Cancer Cell Lines

Assessment of concentration and penetration depth of cisplatin in human lung tissue after decortication and hyperthermic exposure

Synthesis, structure and in vitro anticancer activity of ruthenium(II) and platinum(II) complexes with chiral aminophosphine ligands

The Effect of Glutathione Peroxidase-1 Knockout on Anticancer Drug Sensitivities and Reactive Oxygen Species in Haploid HAP-1 Cells

Collaborators (11)

Daniel Baecker

Andreas Link

Tomasz Plech

Elias Eger

Lukas Schulig

Louis Schmidt

Małgorzata Szczesio

Carola Schulzke

Anita Kornicka

Maria Gdaniec

Izabela Korona-Glowniak

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