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Paul Ekert

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Group Leader, Translational Tumour Biology

Children's Cancer Institute Australia

Australia

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Recent Grants

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Recovering lost therapeutic opportunities in high-risk paediatric cancer - novel drivers of receptor tyrosine kinase activation

Open Date: 2023-12-15

Close Date:

Grant: Close

MRFF Clinical Trials Activity, 2021 Rare Cancers, Rare Diseases and Unmet Need - A Platform trial of combination precision guided therapies for high risk childhood cancer.

Open Date: 2021-01-01

Close Date: 2024-01-01

Grant: Close

EPCD00015 ZERO Childhood Cancer Phase 2.

Open Date: 2020-01-01

Close Date: 2025-01-01

Grant: Close

Cas13 mRNA silencing: a new approach to treating incurable childhood cancers

Open Date: 2020-01-01

Close Date: 2022-01-01

Grant: Close

Unlocking hidden cancer drivers using transcriptome data

Open Date: 2018-01-01

Close Date: 2020-12-31

Articles (20)

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Collaborators (16)

Hansen Kosasih

Children's Cancer Institute Australia

AUSTRALIA

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Gabor Tax

Children's Cancer Institute Australia

AUSTRALIA

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Brett Stringer

Flinders University

AUSTRALIA

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Daniel Thomas

University of Adelaide

AUSTRALIA

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Clare Slaney

Senior Research Fellow

Peter MacCallum Cancer Institute

AUSTRALIA

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Nicholas Gottardo

University of Western Australia

AUSTRALIA

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Mark Cowley

Conjoint Professor

University of New South Wales

AUSTRALIA

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Matthew McKay

University of Melbourne

AUSTRALIA

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Richard Lock

Head

Children's Cancer Institute Australia

AUSTRALIA

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Vanessa Tyrrell

Co-Head of Division - Peronalised Medicine

Children's Cancer Institute Australia

AUSTRALIA

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Wayne Nicholls

Clinical Director and Associate Professor

University of Queensland

AUSTRALIA

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Chelsea Mayoh

Children's Cancer Institute Australia

AUSTRALIA

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Joseph Rosenbluh

Lab Head

MONASH UNIVERSITY

AUSTRALIA

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Syed Faraz Ahmed

University of Melbourne

AUSTRALIA

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Clare Scott

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Rishi Kotecha

Laboratory Head

Telethon Kids Institute

AUSTRALIA

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Paul Ekert

Research Interests

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Recent Grants

Articles (20)

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Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer.

Precision-guided therapy in H3K27-altered diffuse midline glioma.

Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young.

IRF2BP2::JAK2 Defines a Novel Kinase-Activating Fusion in Pediatric T-Cell Acute Lymphoblastic Leukemia

PDGFRA in paediatric high-grade glioma – target or distraction?

A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

Precision-guided treatment in high-risk pediatric cancers

A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax

Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing

Novel paediatric case of a spinal high-grade astrocytoma with piloid features in a patient with Noonan Syndrome

Patient Experience of Complex Genomic Sequencing Exploring Patient Preference, Barriers, and Enablers for Delivery

Author Correction: Functional precision medicine for pediatric cancers

Functional precision medicine for pediatric cancers

Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes

Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities

T<sub>STEM</sub>-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models.

Collaborators (16)

Hansen Kosasih

Gabor Tax

Brett Stringer

Daniel Thomas

Clare Slaney

Nicholas Gottardo

Mark Cowley

Matthew McKay

Richard Lock

Vanessa Tyrrell

Wayne Nicholls

Chelsea Mayoh

Joseph Rosenbluh

Syed Faraz Ahmed

Clare Scott

Rishi Kotecha

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