Paul Ross

Professor at University College Cork

University College Cork
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Positions (1)

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Paul Ross

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University College Cork

Post-Doctoral Researcher in Metagenomic Sequencing and Infant Probiotic Trials at APC Microbiome Ireland

Position Overview: The APC Microbiome Ireland at University College Cork is seeking a highly motivated post-doctoral researcher for a 24-month, full-time, industry-funded project focused on metagenomic sequencing and analysis of infant probiotic trials. This research aims to investigate the effects of probiotics on the composition and function of the infant microbiome, as well as related health outcomes. The successful candidate will join a renowned team specializing in early life microbiome research. Research Focus: The project will utilize advanced metagenomic and bioinformatics approaches, particularly shotgun sequencing, to analyze data from infant probiotic intervention studies. The research will explore how probiotics influence microbial communities and functional genomics, with the ultimate goal of understanding their impact on infant health. Institution and Environment: University College Cork is a leading research institution, and APC Microbiome Ireland is internationally recognized for its expertise in microbiome science. The postdoctoral fellow will benefit from a collaborative, multidisciplinary environment and access to state-of-the-art facilities. Funding and Duration: This is a fixed-term, full-time post for 24 months, with a competitive salary ranging from €46,306 to €52,863 (IUA PD1 Salary Scale). The project is industry-funded and not part of an EU research framework programme. Eligibility and Requirements: Applicants must hold a PhD or equivalent in biological sciences or a related field and demonstrate excellent English language skills. Strong expertise in molecular biology and bioinformatics, especially with shotgun sequencing datasets, is essential. Experience in metagenomic analysis and microbiome research is highly desirable. The position is open to international candidates, and UCC can facilitate hosting agreements for non-EEA nationals. Please note that prior completion of PD1 or PD2 levels in another Irish HEI may affect eligibility. Application Process: Applications must be submitted online via the UCC vacancy portal ( https://ore.ucc.ie/ ) by 12 noon (Irish Local Time) on Friday, December 12th, 2025. Informal enquiries can be directed to Professor Paul Ross at [email protected] . Interviews will be conducted online the week following the application deadline. Late applications will not be considered. Commitment to Diversity: University College Cork is committed to fostering an inclusive and diverse workplace. Applications from underrepresented groups are encouraged, and the university’s equal opportunities and diversity policies can be found on their website. Further Information: For more details about the position and application process, visit the UCC HR vacancies page or contact the HR department at [email protected] .

10 months ago

Articles (11)

Winogradskyella bathintestinalis sp. nov., isolated from the intestine of the deep-sea loosejaw dragonfish, Malacosteus niger

A novel bacterial strain, APC 3343 T , was isolated from the intestine of a deep-sea loosejaw dragon fish, Malacosteus niger , caught at a depth of 1000 m in the Northwest Atlantic Ocean. Cells were aerobic, rod-shaped, yellow/orange-pigmented, non-motile and Gram-negative. Growth of strain APC 3343 T was observed at 4–30 °C (optimum, 21–25 °C), pH 5.5–10 (optimum, pH 7–8) and 0.5–8 % (w/v) NaCl (optimum, 2–4 %). Phylogenetic analysis based on 16S rRNA gene sequences showed that strain APC 3343 T was most closely related to members of the genus Winogradskyella , with the most closely related type strains being Winogradskyella algae Kr9-9 T (98.46 % identity), Winogradskyella damuponensis F081-2 T (98.07 %), Winogradskyella eximia CECT 7946 T (97.93 %), Winogradskyella litoriviva KMM 6491 T (97.79 %) and Winogradskyella endarachnes HL2-2 T (97.79 %). Major fatty acids (>10 % of total) were iso-C 16 : 0 3-OH, iso-C 15 : 0 , anteiso-C 15 : 0 and iso-C 17 : 0 3-OH. The predominant respiratory quinone was menaquinone-6 (MK-6). Polar lipids were phosphatidylethanolamine, three unknown aminolipids and eight unknown lipids. The draft genome sequence was 3.8 Mb in length with a G+C content of 33.43 mol%. Based on the phenotypic characteristics and phylogenetic analysis, strain APC 3343 T is deemed to be a novel species of the genus Winogradskyella <

Year:

2023

After a century of nisin research - where are we now?

It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in the same year that penicillin was first described. Over the last 100 years this small, highly modified pentacyclic peptide has not only found success in the food industry as a preservative but has also served as the paradigm for our understanding of the genetic organization, expression, and regulation of genes involved in lantibiotic biosynthesis—one of the few cases of extensive post-translation modification in prokaryotes. Recent developments in understanding the complex biosynthesis of nisin have shed light on the cellular location of the modification and transport machinery and the co-ordinated series of spatio-temporal events required to produce active nisin and provide resistance and immunity. The continued unearthing of new natural variants from within human and animal gastrointestinal tracts has sparked interest in the potential application of nisin to influence the microbiome, given the growing recognition of the role the gastrointestinal microbiota plays in health and disease. Moreover, interdisciplinary approaches have taken advantage of biotechnological advancements to bioengineer nisin to produce novel variants and expand nisin functionality for applications in the biomedical field. This review will discuss the latest progress in these aspects of nisin research.

Year:

2023

Collaborators (5)

Crystal Johnson, PhD

Assistant Professor

University of Oklahoma Health Sciences Center

UNITED STATES

Ghjuvan Grimaud

Assistant Professor

Lund University

SWEDEN

Colin Hill

Lecturer/Professor

University College Cork

IRELAND

Song Miao

Adjunct Professor

University College Cork

IRELAND

Colin Hill

University College Cork

IRELAND
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