Pauline Soulas-Sprauel

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Professor/Hospital practitioner (PU-PH)

University of Strasbourg

France

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About

Professor Pauline Soulas-Sprauel is a hospital practitioner (PU-PH) at the University of Strasbourg, France. Her research focuses on immunology, particularly T cell exhaustion, B cell tolerance, and the implications of genetic variants in autoimmune diseases. She has published extensively on topics including the role of STING signaling in immune responses and the mechanisms underlying primary antiphospholipid syndrome.

Recent Grants

Grant: Close

Role of Sting in lymphocyte development and function

Open Date: 2020-01-01

Close Date: 2024-06-01

Grant: Close

Personalis

Open Date: 2019-09-01

Close Date: 2022-08-01

Grant: Close

RARENET

Open Date: 2016-01-01

Close Date: 2019-12-01

Grant: Close

Lupus multiplex families in the identification of new gene defects with strong phenotypic effects: from gene discovery to gene function

Open Date: 2014-10-01

Close Date: 2018-09-01

Grant: Close

Functional genomics to dissect complex human lupus phenotype

Open Date: 2014-02-01

Close Date: 2018-02-01

Articles (11)

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2022

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2022

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2021

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2021

Collaborators (17)

Raphaël Carapito

University of Strasbourg

FRANCE

Pauline Soulas-Sprauel

Research Interests

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About

Recent Grants

Articles (11)

Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice

Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?

An immunogenomic exome landscape of triple positive primary antiphospholipid patients

Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome

The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models

mTOR Activation Underlies Enhanced B Cell Proliferation and Autoimmunity in PrkcdG510S/G510S Mice

Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown.

Complex Allele with Additive Gain-of-Function STING1 Variants in a Patient with Cavitating Lung Lesions and Aspergillosis

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells

B cells in primary antiphospholipid syndrome: Review and remaining challenges

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.

Collaborators (17)

Raphaël Carapito

Erik Nelson

Lionel Apetoh

Joo Song

Laura Oksa

Thierry Martin

Vu Ngo

Alexandre Belot

Francesco Carbone

Peng Zhang

Toby Lawrence

Chengsong Zhu

Sophie Jung

Vincent Gies

Frédérique Végran

Sophie Janssens

Seiamak Bahram

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