Pavel Krejci

Assitant professor, Lab leader

Masaryk University

Czech Republic

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About

Dr. Pavel Krejci is an Assistant Professor and Lab Leader at Masarykova univerzita in the Czech Republic. His research primarily focuses on the mechanisms of cell signaling influenced by fibroblast growth factor receptors and the endoplasmic reticulum stress response. Recent publications include studies on protein interactions using in-cell NMR and the therapeutic implications of mouse models in understanding human diseases, such as achondroplasia.

Articles (21)

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2025

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2025

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2024

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2024

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2024

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (13)

Adolf Koudelka

University of Pittsburgh

UNITED STATES

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Wenjuan Zhang

Assistant Professor

Cedars-Sinai Medical Center

UNITED STATES

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Ivan Duran

Professor

University of Malaga

SPAIN

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Tomáš Bárta

Masaryk University

CZECH REPUBLIC

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Lap Hang Tse

University of Oxford

UNITED KINGDOM

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Martyna Biaduń

University of Wrocław

POLAND

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Deborah Krakow

UNITED STATES

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Julien Cros

Institut Pasteur

FRANCE

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Alexandru Nita

Institute of Animal Physiology and Genetics

CZECH REPUBLIC

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Canan Çeliker

Masaryk University

CZECH REPUBLIC

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Tomasz Radaszkiewicz

Masaryk University

CZECH REPUBLIC

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Michaela Kavková

Masaryk University

CZECH REPUBLIC

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Václav Němec

Goethe University Frankfurt

GERMANY

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Pavel Krejci

Research Interests

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About

Articles (21)

Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer

Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors.

FGFR2 residence in primary cilia is necessary for epithelial cell signaling.

Increased thermal stability of FGF10 leads to ectopic signaling during development.

Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models.

Ligand bias underlies differential signaling of multiple FGFs via FGFR1

Ligand bias underlies differential signaling of multiple FGFs via FGFR1

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations

Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

4-PBA treatment improves bone phenotypes in the Aga2 mouse model of osteogenesis imperfecta.

A registry of achondroplasia: a 6-year experience from the Czechia and Slovak Republic

Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model.

LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters.

Cilia kinases in skeletal development and homeostasis

Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling

An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.

Expanding horizons of achondroplasia treatment: current options and future developments.

Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.

Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.

Collaborators (13)

Adolf Koudelka

Wenjuan Zhang

Ivan Duran

Tomáš Bárta

Lap Hang Tse

Martyna Biaduń

Deborah Krakow

Julien Cros

Alexandru Nita

Canan Çeliker

Tomasz Radaszkiewicz

Michaela Kavková

Václav Němec

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