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Paweł Borowiecki

Assistant Professor

University of Warsaw

Poland

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Research Interests

Biochemical Engineering

40%

Organic Chemistry

70%

Organic Reactions

50%

Chemical Synthesis

40%

Biocatalysis

40%

Enzyme Engineering

30%

Catalysis

30%

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Recent Grants

Grant: Close

Novel chemoenzymatic strategies in asymmetric synthesis of the selected pharmaceuticals using recombinant oxydoreductases and hydrolases as biocatalysts.

Open Date: 2020-06-01

Close Date: 2023-07-01

Grant: Close

"Chemoenzymatic synthesis of optically actively γ-arylo-γ-butyrolactones using microorganisms and recombinant alcoholic dehydrogenases as a versatile tool in the preparation of innovative neuroleptics"

Open Date: 2019-01-01

Close Date: 2019-12-01

Grant: Close

"Towards highly efficient biocatalysts for deracemization of 1-(β- hydroxypropyl)indoles"

Open Date: 2017-06-01

Close Date: 2018-06-01

Grant: Close

"Enzymatic catalysis as a versatile tool for the synthesis of 1,3- dimethylxanthine derivatives with potential anticancer activity"

Open Date: 2015-01-01

Close Date: 2016-01-01

Grant: Close

‘Development of Science—the development of the region—scholarship and accompanying support for Mazovia postgraduate students’

Open Date: 2014-02-01

Close Date: 2014-12-01

Paweł Borowiecki

Assistant Professor

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Recent Grants

Articles20

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Front Cover Picture: Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten (Adv. Synth. Catal. 12/2025)

Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water

Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water

Innentitelbild: Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water (Angew. Chem. 8/2025)

Inside Cover: Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water (Angew. Chem. Int. Ed. 8/2025)

ADH‐Catalyzed Biooxidation of (Hetero)aromatic sec‐Alcohols to Ketones Employing Vinyl Acetate as Acetaldehyde Surrogate

One-Pot Sequential Two-Step Photo-Biocatalytic Deracemization of sec-Alcohols Combining Photocatalytic Oxidation and Bioreduction

An experimental and computational investigation of the cyclopentene-containing peptide-derived compounds: focus on pseudo-cyclic motifs via intramolecular interactions

Vinyl 3‐(Dimethylamino)propanoate as an Irreversible Acyl Donor Reagent in a Chromatography‐free Lipase‐Catalyzed Kinetic Resolution of sec‐Alcohols

Chemoenzymatic Synthesis of Tenofovir

Synthesis and Anticancer Activity of Novel Dual Inhibitors of Human Protein Kinases CK2 and PIM-1

Chemoenzymatic Synthesis of Optically Active Alcohols Possessing 1,2,3,4-Tetrahydroquinoline Moiety Employing Lipases or Variants of the Acyltransferase from Mycobacterium smegmatis

Chemoenzymatic Synthesis of Optically Active Ethereal Analog of iso-Moramide—A Novel Potentially Powerful Analgesic

Biocatalytic hydrogen-transfer to access enantiomerically pure proxyphylline, xanthinol, and diprophylline

Expanding Access to Optically Active Non-Steroidal Anti-Inflammatory Drugs via Lipase-Catalyzed KR of Racemic Acids Using Trialkyl Orthoesters as Irreversible Alkoxy Group Donors

Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system

Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol

Supramolecular synthon hierarchy in cyclopropyl-containing peptide-derived compounds

From Waste to Value—Direct Utilization of α-Angelica Lactone as a Nonconventional Irreversible Acylating Agent in a Chromatography-Free Lipase-Catalyzed KR Approach toward sec-Alcohols

Collaborators5

Wolfgang Kroutil

Izabela D. Madura

Martin Breza

Aleksandra Rudzka

Marcin Poterała

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