Paweł Borowiecki

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Assistant Professor

University of Warsaw

Poland

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About

Paweł Borowiecki is an Assistant Professor at Warsaw University of Technology in Poland. His research areas focus on enzymatic and photocatalytic processes, including the development of photo-biocatalytic redox systems for asymmetric synthesis and the dynamic kinetic resolution of secondary alcohols. Recent publications highlight innovative methodologies for the synthesis of optically active amines and the investigation of pseudo-cyclic peptide motifs.

Recent Grants

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Novel chemoenzymatic strategies in asymmetric synthesis of the selected pharmaceuticals using recombinant oxydoreductases and hydrolases as biocatalysts.

Open Date: 2020-06-01

Close Date: 2023-07-01

Grant: Close

"Chemoenzymatic synthesis of optically actively γ-arylo-γ-butyrolactones using microorganisms and recombinant alcoholic dehydrogenases as a versatile tool in the preparation of innovative neuroleptics"

Open Date: 2019-01-01

Close Date: 2019-12-01

Grant: Close

"Towards highly efficient biocatalysts for deracemization of 1-(β- hydroxypropyl)indoles"

Open Date: 2017-06-01

Close Date: 2018-06-01

Grant: Close

"Enzymatic catalysis as a versatile tool for the synthesis of 1,3- dimethylxanthine derivatives with potential anticancer activity"

Open Date: 2015-01-01

Close Date: 2016-01-01

Grant: Close

‘Development of Science—the development of the region—scholarship and accompanying support for Mazovia postgraduate students’

Open Date: 2014-02-01

Close Date: 2014-12-01

Articles (20)

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2021

Collaborators (5)

Wolfgang Kroutil

Graz University of Technology

AUSTRIA

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Izabela D. Madura

associate professor

University of Warsaw

POLAND

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Martin Breza

SLOVAKIA

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Aleksandra Rudzka

University of Warsaw

POLAND

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Marcin Poterała

University of Warsaw

POLAND

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Paweł Borowiecki

Research Interests

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About

Recent Grants

Articles (20)

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Front Cover Picture: Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten (Adv. Synth. Catal. 12/2025)

Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water

Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water

Innentitelbild: Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water (Angew. Chem. 8/2025)

Inside Cover: Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water (Angew. Chem. Int. Ed. 8/2025)

ADH‐Catalyzed Biooxidation of (Hetero)aromatic sec‐Alcohols to Ketones Employing Vinyl Acetate as Acetaldehyde Surrogate

One-Pot Sequential Two-Step Photo-Biocatalytic Deracemization of sec-Alcohols Combining Photocatalytic Oxidation and Bioreduction

An experimental and computational investigation of the cyclopentene-containing peptide-derived compounds: focus on pseudo-cyclic motifs via intramolecular interactions

Vinyl 3‐(Dimethylamino)propanoate as an Irreversible Acyl Donor Reagent in a Chromatography‐free Lipase‐Catalyzed Kinetic Resolution of sec‐Alcohols

Chemoenzymatic Synthesis of Tenofovir

Synthesis and Anticancer Activity of Novel Dual Inhibitors of Human Protein Kinases CK2 and PIM-1

Chemoenzymatic Synthesis of Optically Active Alcohols Possessing 1,2,3,4-Tetrahydroquinoline Moiety Employing Lipases or Variants of the Acyltransferase from Mycobacterium smegmatis

Chemoenzymatic Synthesis of Optically Active Ethereal Analog of iso-Moramide—A Novel Potentially Powerful Analgesic

Biocatalytic hydrogen-transfer to access enantiomerically pure proxyphylline, xanthinol, and diprophylline

Expanding Access to Optically Active Non-Steroidal Anti-Inflammatory Drugs via Lipase-Catalyzed KR of Racemic Acids Using Trialkyl Orthoesters as Irreversible Alkoxy Group Donors

Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system

Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol

Supramolecular synthon hierarchy in cyclopropyl-containing peptide-derived compounds

From Waste to Value—Direct Utilization of α-Angelica Lactone as a Nonconventional Irreversible Acylating Agent in a Chromatography-Free Lipase-Catalyzed KR Approach toward sec-Alcohols

Collaborators (5)

Wolfgang Kroutil

Izabela D. Madura

Martin Breza

Aleksandra Rudzka

Marcin Poterała

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