Regio- and stereoselective functionalisation reactions like C–H oxidation are of high importance for instance for the valorization of renewables like fatty acids by α-hydroxylation.

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Year:

2024

ADH‐Catalyzed Biooxidation of (Hetero)aromatic sec‐Alcohols to Ketones Employing Vinyl Acetate as Acetaldehyde Surrogate

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Year:

2024

Coupling photocatalytic trifluoromethylation with biocatalytic stereoselective ketone reduction in continuous flow

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Year:

2024

Stereocomplementary Unspecific Peroxygenases for Asymmetric Anti-Markovnikov Wacker-Type Oxidation and Epoxidation of Styrenes

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Year:

2024

Cyclic Deracemization of rac‐Sulfoxides via Alternating Biocatalytic Reduction and Light‐Dependent Oxidation Employing Eosin Y as Photocatalyst

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Year:

2024

Old Yellow Enzymes as Oxime Reductases: New Variants by Substrate‐Based Enzyme Engineering

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Year:

2024

Solvent concentration at 50% protein unfolding may reform enzyme stability ranking and process window identification

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Year:

2024

Multistep Biooxidation of 5‐(Hydroxymethyl)furfural to 2,5‐Furandicarboxylic Acid with H2O2 by Unspecific Peroxygenases

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Year:

2024

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

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Year:

2024

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

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Year:

2024

Deciphering the Unconventional Reduction of C═N Bonds by Old Yellow Enzymes Using QM/MM

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Year:

2024

Biocatalytic sulfation of aromatic and aliphatic alcohols catalyzed by arylsulfate sulfotransferases

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Year:

2024

Chemoenzymatic Synthesis of Tenofovir

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Year:

2023

Exciting Enzymes: Current State and Future Perspective of Photobiocatalysis

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Year:

2023

Biocatalytic Transamination of Aldolase‐Derived 3‐Hydroxy Ketones

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Year:

2023

Mechanistic Insights into the Ene-Reductase-Catalyzed Promiscuous Reduction of Oximes to Amines

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Year:

2023

Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction

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Year:

2023

Front Cover Picture: Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction (Adv. Synth. Catal. 13/2023)

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Year:

2023

Rapid, Label‐Free Screening of Diverse Biotransformations by Flow‐Injection Mass Spectrometry

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Year:

2023

Anaerobic demethylation of guaiacyl-derived monolignols enabled by a designed artificial cobalamin methyltransferase fusion enzyme

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Year:

2023

Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis

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Year:

2023

Chemoenzymatic Synthesis of Optically Active Alcohols Possessing 1,2,3,4-Tetrahydroquinoline Moiety Employing Lipases or Variants of the Acyltransferase from Mycobacterium smegmatis

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Year:

2022

Collaborators (14)

Marc Nowaczyk

Professor

University of Rostock

GERMANY

Bastian Daniel

Graz University of Technology

AUSTRIA

Karl Gruber

Full professor

Graz University of Technology

AUSTRIA

Selin Kara

Head of the Institute / Prof. Dr.-Ing. habil.

Leibniz University Hannover

GERMANY

Pere Clapes

Professor

SPAIN

Willem van Berkel

Emeritus Professor Molecular Enzymology

Wageningen University & Research

NETHERLANDS

Jelena Spasic

Graz University of Technology (90000)

AUSTRIA

Paula Tamagnini

Professora Associada

University of Porto

PORTUGAL

Christoph K. Winkler

AUSTRIA

Sandy Schmidt

Assistant professor

Rijksuniversiteit Groningen

NETHERLANDS

Robert Kourist

Univ.-Prof. at Graz University of Technology

Graz University of Technology

AUSTRIA

Aleksandra Rudzka

University of Warsaw

POLAND

Caroline Paul

Assistant Professor

Delft University of Technology

NETHERLANDS

Paweł Borowiecki

Assistant Professor

University of Warsaw

POLAND

Wolfgang Kroutil

Research Interests

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Articles (31)

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Front Cover Picture: Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten (Adv. Synth. Catal. 12/2025)

Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water

Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water

Innentitelbild: Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water (Angew. Chem. 8/2025)

Inside Cover: Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water (Angew. Chem. Int. Ed. 8/2025)

Merging Peptide and Enzyme Catalysis in a Single Protein Domain Bearing Two Separated Active Sites

C–C Bond Cleavage in the Late-Stage Biosynthesis of Huperzine Alkaloids Occurs via Enzymatic Retro-Aza-Prins Reaction

Correction for “Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity”

Preparative regio- and stereoselective α-hydroxylation of medium chain mono- and dicarboxylic fatty acids

ADH‐Catalyzed Biooxidation of (Hetero)aromatic sec‐Alcohols to Ketones Employing Vinyl Acetate as Acetaldehyde Surrogate

Coupling photocatalytic trifluoromethylation with biocatalytic stereoselective ketone reduction in continuous flow

Stereocomplementary Unspecific Peroxygenases for Asymmetric Anti-Markovnikov Wacker-Type Oxidation and Epoxidation of Styrenes

Cyclic Deracemization of rac‐Sulfoxides via Alternating Biocatalytic Reduction and Light‐Dependent Oxidation Employing Eosin Y as Photocatalyst

Old Yellow Enzymes as Oxime Reductases: New Variants by Substrate‐Based Enzyme Engineering

Solvent concentration at 50% protein unfolding may reform enzyme stability ranking and process window identification

Multistep Biooxidation of 5‐(Hydroxymethyl)furfural to 2,5‐Furandicarboxylic Acid with H2O2 by Unspecific Peroxygenases

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

Deciphering the Unconventional Reduction of C═N Bonds by Old Yellow Enzymes Using QM/MM

Biocatalytic sulfation of aromatic and aliphatic alcohols catalyzed by arylsulfate sulfotransferases

Chemoenzymatic Synthesis of Tenofovir

Exciting Enzymes: Current State and Future Perspective of Photobiocatalysis

Biocatalytic Transamination of Aldolase‐Derived 3‐Hydroxy Ketones

Mechanistic Insights into the Ene-Reductase-Catalyzed Promiscuous Reduction of Oximes to Amines

Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction

Front Cover Picture: Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction (Adv. Synth. Catal. 13/2023)

Rapid, Label‐Free Screening of Diverse Biotransformations by Flow‐Injection Mass Spectrometry

Anaerobic demethylation of guaiacyl-derived monolignols enabled by a designed artificial cobalamin methyltransferase fusion enzyme

Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis

Chemoenzymatic Synthesis of Optically Active Alcohols Possessing 1,2,3,4-Tetrahydroquinoline Moiety Employing Lipases or Variants of the Acyltransferase from Mycobacterium smegmatis

Collaborators (14)

Marc Nowaczyk

Bastian Daniel

Karl Gruber

Selin Kara

Pere Clapes

Willem van Berkel

Jelena Spasic

Paula Tamagnini

Christoph K. Winkler

Sandy Schmidt

Robert Kourist

Aleksandra Rudzka

Caroline Paul

Paweł Borowiecki

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