Peter Igarashi
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United StatesResearch Interests
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Recent Grants
Grant: Close
MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
Open Date: 2009-09-22
Close Date: 2012-07-31
Grant: Close
Pathogenesis of PKD in Mice Lacking Renal Cilia
Open Date: 2004-03-01
Close Date: 2009-09-15
Grant: Close
Epithelial Cell Linage in the Kidney and Genitourinary Tract
Open Date: 2004-01-01
Close Date: 2007-11-30
Grant: Close
TRANSCRIPTION FACTORS AND RENAL DEVELOPMENT
Open Date: 1992-09-30
Close Date: 2004-08-31
Grant: Close
Regulation of kidney-Specific Gene Expression
Open Date: 1991-04-15
Close Date: 2011-06-30
Articles (3)
This study identified scAAV/DJ as effective in transducing epithelial cells of the metanephric organ culture (MOC). We used scAAV/DJ shRNA to knockdown Pvt1 in cystic MOCs derived from Pkd1-null embryos. Downregulation of Pvt1 reduced cyst growth and decreased levels of c-MYC protein. These data suggest that suppression of Pvt1 activity in autosomal dominant polycystic kidney disease might reduce cyst growth.
Year:
2022
Year:
2020
Year:
2020
Collaborators (2)
Vishal Patel
Associate Professor with Tenure
University of Texas Southwestern Medical Center
Karam S. Aboudehen
University of Minnesota
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