Peter K Vogt

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Scripps Research Institute

United States

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Peter K Vogt is a Professor at the Scripps Research Institute in the United States. His research focuses on structural biology, particularly the mechanisms of phosphoinositide 3-kinase (PI3Kα) and the role of long non-coding RNAs in cancer. His recent articles explore topics such as cryo-EM analysis of PI3Kα, the interaction of ligands with this enzyme, and the implications of MYC-regulated lncRNAs in cell proliferation.

Recent Grants

Grant: Close

Cancer genes: translating basics to applications

Open Date: 2016-01-08

Close Date: 2022-12-31

Articles (11)

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2020

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2020

Collaborators (2)

Alexander Lund Nielsen

EPFL (École Polytechnique Fédérale de Lausanne)

SWITZERLAND

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Alessandro Sartori

University of Zurich

SWITZERLAND

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Peter K Vogt

Research Interests

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About

Recent Grants

Articles (11)

Structural insights into the interaction of three Y-shaped ligands with PI3Kα

Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα).

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2.

Long Non-Coding RNAs as “MYC Facilitators”

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.

Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay

Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications.

Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.

A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation

Collaborators (2)

Alexander Lund Nielsen

Alessandro Sartori

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