Piyusha Pagare

Research Assistant Professor

Virginia Commonwealth University

United States

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Piyusha Pagare is a Research Assistant Professor at Virginia Commonwealth University, USA. Her research focuses on opioid receptor modulators, pharmacological applications of antisickling agents, and the development of nonaddictive pain management treatments. Recent work includes the discovery of novel compounds for the treatment of opioid use disorder and in-depth studies on the pharmacological profiles of potential therapeutic agents.

Articles (11)

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2020

Collaborators (6)

Samuel Obeng

Assistant Professor

Samford University

UNITED STATES

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Yan Zhang

Virginia Commonwealth University

UNITED STATES

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Martin Safo

Professor

Virginia Commonwealth University

UNITED STATES

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Tarek A. Ahmed

SAUDI ARABIA

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Abdelsattar M. Omar

SAUDI ARABIA

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Moustafa E. El-Araby

SAUDI ARABIA

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Piyusha Pagare

Research Interests

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Articles (11)

Systematic Structure–Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments

The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

Discovery of 6α-Thiazolylcarboxamidonaltrexamine Derivative (NTZ) as a Potent and Central Nervous System Penetrant Opioid Receptor Modulator with Drug-like Properties for Potential Treatment of Opioid Use Disorder

Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression

Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

Structural Alterations of the “Address” Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity

Preclinical Characterization and Development on NAQ as a Mu Opioid Receptor Partial Agonist for Opioid Use Disorder Treatment

Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists

Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Collaborators (6)

Samuel Obeng

Yan Zhang

Martin Safo

Tarek A. Ahmed

Abdelsattar M. Omar

Moustafa E. El-Araby

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