Professor Jonathan C Strefford

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Professor of Molecular Oncology

University of Southampton

United Kingdom

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About

Professor Jonathan C Strefford is a Professor of Molecular Oncology at the University of Southampton, United Kingdom. His research focuses on the genomic and molecular landscape of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and splenic marginal zone lymphoma. Recent publications include studies on prognostic gene mutations in CLL, the impact of miRNAs on transcriptional differences, and the biological implications of whole-genome sequencing outcomes.

Recent Grants

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Integrating genetics and epigenetics to unravel their clinical importance in CLL

Open Date: 2014-08-01

Close Date: 2017-08-01

Grant: Close

Importance of SF3B1 mutations in the diagnosis, prognosis and biology of chronic lymphocytic leukaemia.

Open Date: 2013-01-14

Close Date: 2016-01-14

Grant: Close

The identification and characterization of novel genetic lesions associated with clinical outcome in patients with Splenic Marginal Zone Lymphoma

Open Date: 2012-07-02

Close Date: 2014-07-02

Grant: Close

The genetic and functional characterization of causative loci targeted by recurrent 3p deletions in patients with chronic lymphocytic leukaemia.

Open Date: 2012-06-01

Close Date: 2016-07-29

Grant: Close

Molecular characterisation of PDE9A rearrangements in ALL patients with iAMP21

Open Date: 2009-01-01

Close Date: 2009-12-31

Articles (12)

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (22)

Francesco Forconi

University of Southampton

UNITED KINGDOM

Professor Jonathan C Strefford

Research Interests

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About

Recent Grants

Articles (12)

The genomic and molecular landscape of splenic marginal zone lymphoma, biological and clinical implications

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY

Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in CLL patients.

<i>TP53</i> Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype

The Genomics of Hairy Cell Leukaemia and Splenic Diffuse Red Pulp Lymphoma

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy.

The association between deaths from infection and mutations of the BRAF, FBXW7, NRAS and XPO1 genes: a report from the LRF CLL4 trial

Single-nucleotide Fcγ receptor polymorphisms do not impact obinutuzumab/rituximab outcome in patients with lymphoma

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior

Collaborators (22)

Francesco Forconi

Jesús María Hernández-Rivas

James Davies

Matthew Blunt

Marek Mraz

Paul Moss

Patrick Duriez

Gian Matteo Rigolin

Geir Åge Løset

María Hernández-Sánchez

Jianguo Zhuang

Lekh Dahal

David Tumbarello

Giorgia Chiodin

Alan Ramsay

Andrea Pepper

Florence Nguyen-Khac

James Allan

Samantha Knight

MJ Calasanz

Sarah Wordsworth

Lars Bullinger

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