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Qizhen Shi

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Professor

Medical College of Wisconsin

United States

Research Interests

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Recent Grants

Grant: Close

Platelet-derived FVIII Gene Therapy of Hemophilia A

Open Date: 2010-07-01

Close Date: 2023-04-30

Grant: Close

Platelet-Specific Gene Therapy of Murine Hemophilia A and Hemophilia A with Inhibitors

Open Date: 2007-01-01

Close Date: 2010-12-31

Grant: Close

Lentivirus-Mediated Platelet-Specific Gene Therapy of Murine Hemophilia A

Open Date: 2005-01-01

Close Date: 2005-12-30

Grant: Close

Site-Specific Expression of Factor VIII (FVIII) Using Transgenes in FVIII-KO-mice

Open Date: 2003-01-01

Close Date: 2004-12-30

Articles (16)

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2026

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2023

Collaborators (8)

Jieqing Zhu

Versiti Blood Research Institute Milwaukee

UNITED STATES

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Tirthadipa Pradhan-Sundd

University of Pittsburgh School of Medicine

UNITED STATES

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Christian Kastrup

Professor

Medical College of Wisconsin

UNITED STATES

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Weiqing Jing

Research Assistant professor

Northwestern University

UNITED STATES

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Woosuk Steve Hur

Research Assistant Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Alexander Dent

Indiana University School of Medicine

UNITED STATES

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Weiguo Cui

Northwestern University

UNITED STATES

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Jerry Leung

The University of British Columbia

CANADA

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Qizhen Shi

Research Interests

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Recent Grants

Articles (16)

Impact of antiplatelet therapy on the hemostatic efficacy of platelet-targeted FVIII gene therapy in hemophilia A mice

Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

A Padua moment for factor VIII gene therapy

The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice

The pivotal role of von Willebrand factor binding to platelet αIIbβ3 in stabilizing the formation of a platelet plug at sites of injury

Small-molecule inhibitor screen to identify mechanisms of sickle hemoglobin clearance by liver endothelium

Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History

Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A

CXCL13/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia

Chemokine CXCL13 facilitates anti-FVIII inhibitory antibody development in hemophilia A patients and murine models

Evaluating clinically translatable conditioning for platelet gene therapy in murine hemophilia A with inhibitors

Anti-mCD20 in combination with α-mCXCL13 monoclonal antibody inhibits anti-FVIII antibody development in hemophilia A mice

Platelet-targeted gene therapy induces immune tolerance in hemophilia and beyond

PACSIN2 regulates platelet integrin β1 hemostatic function

Pre-existing anti-factor VIII immunity alters therapeutic platelet-targeted factor VIII engraftment following busulfan conditioning through cytotoxic CD8 T cells

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

Collaborators (8)

Jieqing Zhu

Tirthadipa Pradhan-Sundd

Christian Kastrup

Weiqing Jing

Woosuk Steve Hur

Alexander Dent

Weiguo Cui

Jerry Leung

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