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Rachel Caspi

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Chief, Immunoregulation Section

National Institutes of Health

United States

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Professors in United States Professors in Immunology Immunology professors in United States

About

Dr. Rachel Caspi is the Chief of the Immunoregulation Section at the National Institutes of Health in the United States. Her research focuses on ocular immune privilege, T cell-mediated disorders, and the roles of immune mediators in autoimmunity, as highlighted in her recent publications. Her work explores essential regulatory mechanisms in ocular immunology and potential therapeutic approaches for T cell-related conditions.

Recent Grants

Grant: Close

Genetic, Cellular and Molecular Mechanisms in Autoimmunity to Retina

Open Date: 2009-01-01

Close Date: 2016-01-01

Articles (11)

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2026

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2023

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Professor

University of California, San Francisco

UNITED STATES

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Rachel Caspi

Research Interests

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About

Recent Grants

Articles (11)

Immune checkpoints in a genetically engineered mouse model of spontaneous autoimmune uveitis.

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity

Genetically engineered eye-colonizing microbes that deliver the anti-inflammatory cytokine interleukin-10 enhance corneal tissue repair

Oral 8-aminoguanine against age-related retinal degeneration

Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells

The production of the chemokine CCL2 by corneal sensory neurons initiates anti-viral immunity at the cornea and trigeminal ganglion.

TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming

Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model

A CD6-targeted antibody-drug conjugate as a potential therapy for T cell–mediated disorders

Mucosal immunology of the ocular surface

Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation

Collaborators (5)

Mary Mattapallil

Jishnu Das

Harinder Singh

Yuanyuan Chen

Matthew Spitzer

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