Rachel Thijssen

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Assistant Professor

Amsterdam UMC Locatie VUmc

Netherlands

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About

Dr. Rachel Thijssen is an Assistant Professor at Amsterdam UMC Locatie VUmc in the Netherlands. Her research primarily focuses on chronic lymphocytic leukaemia (CLL), particularly the mechanisms of venetoclax sensitivity and resistance. Recent articles authored by Dr. Thijssen delve into the role of NOTCH1 activation, JAK–STAT signaling, and single-cell multiomics in understanding CLL treatments. She is actively exploring innovative therapeutic strategies to overcome drug resistance in B-cell malignancies.

Recent Grants

Grant: Open

Resolving blood cancer complexity and therapeutic resistance with single-cell technologies, using venetoclax resistance in AML as a prime model

Open Date: 2023-03-01

Close Date: 2028-02-01

Grant: Close

Elucidating leukaemia cell plasticity in resistance to targeted therapy

Open Date: 2022-03-01

Close Date: 2024-02-01

Grant: Close

Identifying rational approaches to enhance the activity of the anti-cancer drug venetoclax

Open Date: 2022-01-01

Close Date: 2024-12-01

Grant: Close

Identifying rational approaches to enhance the activity of BH3 mimetic drugs in blood cancers

Open Date: 2021-11-04

Close Date:

Grant: Close

Developing strategies to overcome venetoclax resistance in chronic lymphocytic leukaemia

Open Date: 2020-03-01

Close Date: 2021-02-01

Articles (11)

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2024

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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Joint Division Head and Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Rachel Thijssen

Research Interests

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About

Recent Grants

Articles (11)

Potential impact of NOTCH1 activation on venetoclax sensitivity in chronic lymphocytic Leukaemia: In vitro insights and clinical implications

JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL

RUV-III-NB: normalization of single cell RNA-seq data.

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Overcoming resistance hurdles

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors

Intact TP53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL.

BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic.

Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells.

Collaborators (14)

Michael B Clark

Audrey S Chan

Ian Majewski

Mei Du

David Huang

Claudia Bruedigam

Ruth Kluck

Alysha De Livera

Yair Prawer

Elaine Willmore

Michael Dengler

Eric Eldering

Fiona Brown

Daniel Gray

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