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Ramon Arens

Associate Professor

Leiden University Medical Center

Netherlands

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Research Interests

Immunology

100%

Virology

50%

Immune Response

70%

T Cell Biology

70%

Vaccinology

40%

Immunotherapy

40%

Dendritic Cell

40%

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Articles14

Metabolic profiling of antigen-specific CD8+ T cells by spectral flow cytometry

Article Link

Year:

2025

Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides.

Article Link

Year:

2023

OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.

Article Link

Year:

2023

Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors.

Article Link

Year:

2023

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

Article Link

Year:

2023

Multiantigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses.

Article Link

Year:

2023

Delayed vaccine-induced CD8+T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

Article Link

Year:

2023

Immunophenotyping beyond the limits of time.

Article Link

Year:

2023

CRISPR Activation Screening Identifies VGLL3-TEAD1-RUNX1/3 as a Transcriptional Complex for PD-L1 Expression.

Article Link

Year:

2022

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.

Article Link

Year:

2022

mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming.

Article Link

Year:

2022

Editorial: Immunity to Cytomegalovirus Infections: Challenges and Therapeutic Opportunities.

Article Link

Year:

2022

Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination.

Article Link

Year:

2022

Dominant Antiviral CD8+ T Cell Responses Empower Prophylactic Antibody-Eliciting Vaccines Against Cytomegalovirus.

Article Link

Year:

2022

Collaborators9

Felix M. Wensveen

CROATIA

Birol Cabukusta

Group leader / Assistant professor

University of Maastricht

NETHERLANDS

Sebenzile Myeni

Assistant Professor

Leiden University Medical Center

NETHERLANDS

Perry Moerland

Assistant professor

Amsterdam University Medical Centers, location AMC

NETHERLANDS

Jacques Neefjes

Professor, head department

Leiden University Medical Center

NETHERLANDS

Klaas P.J.M. van Gisbergen

NETHERLANDS

Ferry Ossendorp

Group Leader, Professor

Leiden University Medical Center

NETHERLANDS

Eric Eldering

groupleader/professor

Academic Medical Center

NETHERLANDS

Margot Linssen

Leiden University Medical Center

NETHERLANDS

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Ramon Arens

Associate Professor

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Research Interests

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Articles14

Metabolic profiling of antigen-specific CD8+ T cells by spectral flow cytometry

Enhanced HPV16 E6/E7<sup>+</sup> tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides.

OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.

Chronic lymphocytic leukemia presence impairs antigen-specific CD8<sup>+</sup> T-cell responses through epigenetic reprogramming towards short-lived effectors.

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

Multiantigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses.

Delayed vaccine-induced CD8+T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

Immunophenotyping beyond the limits of time.

CRISPR Activation Screening Identifies VGLL3-TEAD1-RUNX1/3 as a Transcriptional Complex for PD-L1 Expression.

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.

mTORC1 signaling in antigen-presenting cells of the skin restrains CD8<sup>+</sup> T cell priming.

Editorial: Immunity to Cytomegalovirus Infections: Challenges and Therapeutic Opportunities.

Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination.

Dominant Antiviral CD8+ T Cell Responses Empower Prophylactic Antibody-Eliciting Vaccines Against Cytomegalovirus.

Collaborators9

Felix M. Wensveen

Birol Cabukusta

Sebenzile Myeni

Perry Moerland

Jacques Neefjes

Klaas P.J.M. van Gisbergen

Ferry Ossendorp

Eric Eldering

Margot Linssen

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