Renate Hukema at Rotterdam University of Applied Sciences - Research Interests, Publications & Academic Profile

Renate Hukema

Lecturer/Research supervisor/Coach

Erasmus University Rotterdam

Netherlands

Has grant

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Research Interests

Cell Biology

20%

Neurology

20%

Ataxia

20%

Genotoxicity

20%

In Vitro Studies

20%

Mouse Genetics

10%

Rna Interference

10%

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Recent Grants

Grant: Close

Targeted molecular approaches towards therapeutic intervention for FXTAS

Open Date: 2015-01-01

Close Date: 2017-01-01

Grant: Close

Experimental approaches towards therapeutic intervention for Fragile X-associated Tremor Ataxia Syndrome

Open Date: 2013-03-01

Close Date: 2016-02-01

Grant: Close

Fragile X premutation and premature ovarian failure (FXPOI); analysis of ovaries from FMR1 CGG repeat mice

Open Date: 2010-09-01

Close Date: 2011-08-01

Articles7

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

Article Link

Year:

2021

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.

Article Link

Year:

2021

Editorial: Proceedings of the "Fourth International Conference of the FMR1 Premutation: Basic Mechanisms, Clinical Involvement and Therapy".

Article Link

Year:

2021

Neuropathology of FMR1-premutation carriers presenting with dementia and neuropsychiatric symptoms.

Article Link

Year:

2021

Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice.

Article Link

Year:

2021

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates.

Article Link

Year:

2020

In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome.

Article Link

Year:

2020

Collaborators3

Krzysztof Sobczak

associated professor

Adam Mickiewicz University in Poznań

POLAND

Ronald A.M. Buijsen

Leiden University Medical Center

NETHERLANDS

Laurens Bosman

Assistant professor

Erasmus MC

NETHERLANDS

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Renate Hukema

Lecturer/Research supervisor/Coach

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Research Interests

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Recent Grants

Articles7

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.

Editorial: Proceedings of the "Fourth International Conference of the <i>FMR1</i> Premutation: Basic Mechanisms, Clinical Involvement and Therapy".

Neuropathology of <i>FMR1</i>-premutation carriers presenting with dementia and neuropsychiatric symptoms.

Inducible expression of human <i>C9ORF72</i> 36x G<sub>4</sub>C<sub>2</sub> hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice.

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates.

<i>In silico, in vitro</i>, and <i>in vivo</i> Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome.

Collaborators3

Krzysztof Sobczak

Ronald A.M. Buijsen

Laurens Bosman

How do Vietnamese students reach out?