Ricarda Richter-Dennerlein
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Ricarda Richter-Dennerlein is an Assistant Professor at the University Medical Center Göttingen, Germany. Her research focuses on mitochondrial ribosome biogenesis and translation, with recent articles addressing topics such as ribosome function, translation termination, and the role of specific factors in mitochondrial processes. She investigates the structural and functional mechanisms that underpin mitochondrial translation and ribosome dynamics.
Positions (1)
Ricarda Richter-Dennerlein
University Medical Center Göttingen
University Medical Center Göttingen (UMG) is recruiting a Postdoctoral Researcher / PostDoc (f/m/d) for the research group of Prof. Dr. Ricarda Richter-Dennerlein in the Department of Molecular Biology. The project focuses on the function and biogenesis of ribosomes in human mitochondria , with a strong emphasis on mitochondrial biology , gene expression , ribosome biogenesis , and related mechanisms of human disease. The group studies how the human mitochondrial ribosome is assembled and regulated, the roles of associated factors, and the quality-control steps that maintain functional ribosomes. The work combines advanced biochemistry , molecular and cellular biology , iPSC culture , cell differentiation, mass spectrometry, and structural biology in a collaborative Göttingen campus environment. The post is embedded in a highly international and research-intensive setting at the University Medical Center Göttingen, with access to local core facilities and collaborators. Eligibility highlights: applicants should hold a PhD in life sciences such as molecular and cell biology, biochemistry, or a related discipline. Experience with stem cells/iPSC culture is important, and analysis of large data sets (transcriptome/proteome) is advantageous. Fluent English is required. The group is looking for a motivated scientist who can work independently and in a team. Funding and terms: fixed-term full-time position for 2 years, with the possibility of extension, paid according to TV-L 13 . How to apply: submit a single PDF containing a motivation statement, CV, copies of degree certificates, and the names/contact details of at least two references. Applications should be submitted through the recruiting portal linked in the post. Informal questions can be directed to Ricarda Richter-Dennerlein at [email protected].
Articles (9)
Year:
2025
Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to the descendance from a bacterial ancestor, some deviations regarding translation factors as well as mRNA characteristics and the applied genetic code are present in human mitochondria. Together, these features are certain challenges during translation the mitochondrion has to handle. Here, we discuss the current knowledge regarding mitochondrial translation focusing on the termination process and the associated quality control mechanisms. We describe how mtRF1a resembles bacterial RF1 mechanistically and summarize in vitro and recent in vivo data leading to the conclusion of mtRF1a being the major mitochondrial release factor. On the other hand, we discuss the ongoing debate about the function of the second codon-dependent mitochondrial release factor mtRF1 regarding its role as a specialized termination factor. Finally, we link defects in mitochondrial translation termination to the activation of mitochondrial rescue mechanisms highlighting the importance of ribosome-associated quality control for sufficient respiratory function and therefore for human health.
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2023
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2022
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2022
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2022
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2022
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2021
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2020
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2020
Collaborators (5)
Hauke Hillen
Assistant Professor
University Medical Center Göttingen
Andreas Linden
University Medical Center Göttingen
Markus T. Bohnsack
Professor
University Medical Center Göttingen
Luis Daniel Cruz‐Zaragoza
-
Katherine E. Bohnsack
-
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