Richard Groen

Assistant Professor

VU University Medical Center

Netherlands

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Richard Groen is an Assistant Professor at VU University Medical Center in the Netherlands. His research focuses on the mechanisms of resistance in multiple myeloma, particularly involving bone marrow mesenchymal stromal cells and CAR T-cell therapies. He has published several recent articles on topics such as intracellular IL-32's role in malignancy, engineered T-cell efficacy, and therapeutic targets in acute myeloid leukemia.

Articles (10)

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (6)

Adam Shahine

MONASH UNIVERSITY

AUSTRALIA

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Christian Buchholz

Paul-Ehrlich-Institut

GERMANY

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Philippe Bousso

FRANCE

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Maria Themeli

Assistant Professor

Amsterdam UMC Locatie VUmc

NETHERLANDS

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Gerrit Jansen

NETHERLANDS

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Sara Gandolfi

University of Helsinki

FINLAND

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Richard Groen

Research Interests

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Articles (10)

Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?

Author Correction: SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia (Leukemia, (2021), 35, 9, (2698-2702), 10.1038/s41375-021-01273-7)

Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant

Bone marrow mesenchymal stromal cells can render multiple myeloma cells resistant to cytotoxic machinery of CAR T cells through inhibition of apoptosis

CD38-specific chimeric antigen receptor expressing natural killer KHYG-1 cells: A proof of concept for an "Off the Shelf" therapy for multiple myeloma

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Collaborators (6)

Adam Shahine

Christian Buchholz

Philippe Bousso

Maria Themeli

Gerrit Jansen

Sara Gandolfi

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