Richard Loeser

Professor

University of North Carolina

United States

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About

Professor Richard Loeser is a faculty member at the University of North Carolina, USA. His research primarily focuses on osteoarthritis, exploring its genetic risk factors, the role of inflammation, and the interactions between obesity and gut microbiome. Recent publications highlight innovative approaches in drug discovery and the significance of chondrocyte biology in understanding and treating osteoarthritis.

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2025

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2021

Collaborators (4)

Ali Mobasheri

Professor of Musculoskeletal Biology

University of Oulu

FINLAND

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Shannon Mihalko

Professor

Wake Forest University

UNITED STATES

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Edward Ip

Professor

Wake Forest School of Medicine

UNITED STATES

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M. Andrea Azcarate-Peril

Associate Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Richard Loeser

Research Interests

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Articles (22)

Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning

The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical development

Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes

Revisiting the Synovium as a Structural Correlate of Pain in Osteoarthritis

Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity

Publisher Correction: Integrin signalling in joint development, homeostasis and osteoarthritis

Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development

Integrin signalling in joint development, homeostasis and osteoarthritis

DNA Damage and Cellular Senescence in Osteoarthritis: An Unexpected Role for Interferon Regulatory Factor 1 in Chondrocyte DNA Repair

Clinical, Health‐Related Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis

The osteoarthritis prevention study (TOPS) - A randomized controlled trial of diet and exercise to prevent Knee Osteoarthritis: Design and rationale

A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery

Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes

Using Mice to Model Human Osteoarthritis: Age, Biologic Sex, and Pain Matter

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes

Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis

Correspondence on ‘Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7’ by Zhang et al

Targeting cellular senescence as a novel treatment for osteoarthritis

Overexpression of Peroxiredoxin 3 in Cartilage Reduces the Severity of Age‐Related Osteoarthritis But Not Surgically Induced Osteoarthritis in Mice

Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity‐Related Osteoarthritis

Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight‐Loss Treatments for Overweight and Obese Adults With Knee Osteoarthritis: Data From a Single‐Center Randomized Trial

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

Collaborators (4)

Ali Mobasheri

Shannon Mihalko

Edward Ip

M. Andrea Azcarate-Peril

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